Paper Information

Journal:   JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   MARCH-APRIL 2016 , Volume 23 , Number 1; Page(s) 151 To 160.
 
Paper: 

ANTICONVULSANT ACTIVITY OF HYDRO-ALCOHOLICEXTRACT OF ZIZIPHORATENUIOR L. ON PENTYLENETETRAZOL INDUCED SEIZURE IN MICE

 
 
Author(s):  PIRI HOSSEIN, ALIMOHAMMADI BENYAMIN, SAEIDI FATEMEH, NADERI FIROZEH, AZHDARI ZARMEHRI HASAN*
 
* DEPARTMENT OF BASIC SCIENCES AND NEUROSCIENCES RESEARCH CENTER, TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, TORBAT HEYDARIYEH, IRAN
 
Abstract: 

Background and Objectives: About half to one percent of the world population suffer from epilepsy.Seizure is the most common symptoms of epilepsy due to abnormal electrical discharge of neurons in the brain. Due to side effects of chemical drugs, herbal plants are widely used to control seizures. In this study, Anticonvulsant activity of hydro-alcoholicextract of (Ziziphoratenuior L.) was investigated in mice.
Materials and Methods: In this study, 40 male mice (25-30 g) were randomly selected and divided into five groups of 8, that included a control group (receiving saline and PTZ) and 4 treatment groups (receiving the extract doses of 150, 300, 600, 900 mg/kg).30 minutes after IP administration with saline (in control group) and different doses of extract (in treatment groups), PTZ (8 0 mg/kg) were injectedAnd were transferred to a special cage immediately and convulsive behaviors were recorded by a camera during the 20 minutes. Then, the different phases of seizure were evaluated.
Results: Extract injection in all doses by dose- dependently delayed the onset time of clonic, tonic and tonic-clonic seizures, but doses of 600 and 900 mg/kg had showed the greatest effect on onset time. The duration time of tonic, clonic and tonic-clonic seizures in animals that received extract also reduced. Extract injection also dose-dependently decreased the rate of mortality and the number of suddenly jumping during seizures, these effects in doses of 600 and 900 mg/kg was significant.
Conclusion: Our study showed that, the hydro-alcoholicextract of (Ziziphoratenuior L.) had an appropriate anticonvulsant activity and it seems the future studies will be necessary to separate its ingredients and understand its mechanism of action.

 
Keyword(s): ZIZIPHORATENUIOR L., ANTICONVULSANT ACTIVITY, PENTYLENETETRAZOL, SEIZURE, MICE
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 76
 
Latest on Blog
Enter SID Blog