Paper Information

Journal:   JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   MARCH-APRIL 2016 , Volume 23 , Number 1; Page(s) 6 To 13.
 
Paper: 

EXAMINATION OF EFFECTS OF ANABOLIC STEROIDS ABUSE ON LIVER ENZYMES AND BLOOD ALBUMIN OF BODYBUILDERS

 
 
Author(s):  RASHIDLAMIR AMIR*, DEHBASHI MOHSEN, KETABDAR BAHAREH
 
* FACULTY OF PHYSICAL EDUCATION AND SPORT SCIENCES, FERDOWSI UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Abstract: 

Background & Objectives: For the past 50 years, anabolic steroids have been at the forefront of the controversy due to their various effects on athletes' performance. So the aim of the present study was to examine the effects of anabolic steroids abuse, during and after the withdrawal of the drug usage, on liver enzymes and blood albumin of bodybuilders.
Materials & Methods: The study is causative-comparative research, and 40 males (Age: 26.62±6.8 years, height: 175.89±9.2 cm, weight: 77.17±12.7) were participated in this study, who were divided into four groups of ten members: athletes are using steroids, athletes with a history of drug usage who had given away its usage at least for 2 months, athletes with a history of at least 6 months of giving away using steroid and athletes with no history of steroid use.12-hour fasting blood samples were collected at eight o' clock in the morning, and the data were analyzed using one-way ANOVA and a post hoc test.
Results: The results of this study showed higher degradation of both enzymes (ALT, AST) in the first group as compared to the other groups (p<%5). The destruction of these two enzymes (AST, ALT) was higher in second group as compared to the third and fourth groups (p<%5). However, the destruction of the two enzymes (ALT, AST) in the third group was not significant as compared to the fourth group. (p<%5). Albumin and (ALP) levels were normal in all groups and their changes were not significant (p>%5).
Conclusion: Steroid drugs have devastating effects on the liver cells. So those, even after two months of stopping drug consumption, their side effects are still apparent in athletes who had used them. But it seems that their negative effects on liver enzymes decrease over time.

 
Keyword(s): LIVER, ALBUMIN, AST, ALT, ALP
 
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