Paper Information

Journal:   JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE   2016 , Volume 34 , Number 1; Page(s) 58 To 65.
 
Paper: 

IMMUNOHISTOCHEMICAL EXPRESSION OF PCNA AND KI-67 IN PERIAPICAL GRANULOMA AND RADICULAR CYST

 
 
Author(s):  SARGOLZAEI SOUDABEH*, ROUFEGARINEJAD AREZOO, SHAMSZADEH SAYNA
 
* DEPT OF ORAL AND MAXILLOFACIAL PATHOLOGY, SCHOOL OF DENTISTRY, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Objective: Periapical Granulomas (PGs) and Radicular Cysts (RCs), as the most common odontogenic lesions have yet unclear pathogenesis. This study was aimed to compare PCNA and Ki-67 expression in PGs and RCs and evaluate their possible relationship with two lesions.
Methods: In this cross-sectional descriptive study, twenty PGs and twenty RCs were evaluated immunohistochemically using an anti-PCNA and anti-Ki-67 polyclonal antibodies. PCNA+ and Ki-67+ cells were counted in connective tissue wall and epithelial lining (in RCs). Statistical analysis was performed by using Mann-Whitney U test and Spearman’s rank correlation coefficient.
Results: In PGs, percentage of PCNA and Ki-67 expression were found 70% and 30%, respectively; In RCs, PCNA and Ki-67 expression were observed 90% and 55%, respectively. Additionally, in RCS, Immunoexpression of PCNA (85%) and Ki-67 (60%) were detected at epithelial lining area. The positive immunoexpression of PCNA in RCs was greater than PGs (p<0.05).
Conclusion Immunoexpression of PCNA and Ki-67 were detected in both lesions which may be mentioned as valuable markers for the prediction of biologic behavior of PGs and RCs.

 
Keyword(s): IMMUNOHISTOCHEMISTRY, KI-67, PCNA, PERIAPICAL GRANULOMA, RADICULAR CYST
 
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