Paper Information

Journal:   JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH   MARCH 2015 , Volume 9 , Number 1; Page(s) 1 To 4.
 
Paper: 

ARTIFICIAL ENDOMETRIAL PREPARATION FOR FROZEN-THAWED EMBRYO TRANSFER WITH OR WITHOUT PRETREATMENT WITH DEPOT GONADOTROPIN RELEASING HORMONE AGONIST IN WOMEN WITH REGULAR MENSES

 
 
Author(s):  AZIMI NEKOO ELHAM, CHAMANI MARYAM, SHAHROKH TEHRANI ENSIEH, HOSSEIN RASHIDI BATOOL, DAVARI TANHA FATEMEH*, KALANTARI VAHID
 
* WOMEN’S HOSPITAL, NORH VILLA AVE., TEHRAN, 14149, IRAN
 
Abstract: 

Objective: To investigate the reproductive outcome of artificial endometrial preparation with exogenous steroids for frozen-thawed embryo transfer with and without pre-treatment with depot gonadotropin releasing hormone agonist (GnRH-a) in women with regular menses.
Materials and methods: This is a prospective randomized clinical trial conducted in two ART centers on 176 women undergoing frozen-thawed embryo transfer. All patients received oral estradiol valerate 4 mg daily from day 2 to day 5 and 6 mg per day from day 6 to the day of the pregnancy test. In day 13 of cycle, an ultrasound examination was performed. After ultrasound confirmation of endometrial thickness (
³8 mm) and no ovarian activity, progesterone in cyclogest supp (800 mg daily) was added. The dose of estradiol would be increased to 8 mg per day if the endometrial thickness was less than 8mm. Two or 3 embryos were transferred via transcervical route 48 hours after the beginning of progesterone administration. In group A (93 patients), Difereline (3.75 mg Im), as a depot GnRH agonist was administered in the midluteal phase (day 21) of previous cycle. In the other group B (n=83) steroid supplementation was commenced without prior pituitary suppression. Chemical and clinical pregnancy rates were compared in two groups.
Results: No significant differences were seen between two groups in terms of chemical pregnancy and clinical pregnancy rates.
Conclusion: The findings support the artificial protocol without any pretreatment suppressive drugs to reduce the adverse side effects of GnRH agonists also to minimize the costs.

 
Keyword(s): FROZEN-THAWED EMBRYO TRANSFER, GNRH AGONIST, ARTIFICIAL CYCLE, ENDOMETRIAL PREPARATION, PREGNANCY OUTCOME
 
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