Paper Information

Journal:   JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH   MARCH 2015 , Volume 9 , Number 1; Page(s) 29 To 33.
 
Paper: 

EFFECTS OF PREOPERATIVE MAGNESIUM SULPHATE ON POST-CESAREAN PAIN, A PLACEBO CONTROLLED DOUBLE BLIND STUDY

 
 
Author(s):  MIRESKANDARI SEYED MOHAMAD, PESTEI KHALIL, HAJIPOUR ASGHAR*, JAFARZADEH AFSHIN, SAMADI SHAHRAM, NABAVIAN OMID
 
* VALIASR HOSPITAL, IMAM HOSPITAL COMPLEX, KESHAVARZ BLVD., TEHRAN, 1413397141, IRAN
 
Abstract: 

Objective: To study the role of preoperative intravenous magnesium sulphate in decreasing postcesarean pain and opioid requirement during first 24hrs.
Materials and methods: In a double blind randomized clinical trial, prior to induction of general anesthesia, fifty elective cesarean candidates were randomly assigned to one of the two groups of placebo or magnesium sulfate. After surgery visual analogue scale (VAS) and infused morphine by PCA during 24 hrs were recorded. The data were analyzed by mann-Whitney -test, analysis of variance, andstudent t- test.
Results: VAS was significantly lower among patients in the magnesium sulphate group at intervals of 1st, 6th & 12th hours after cesarean section (C/S) with the mean scales of (48.9 ± 19.6 VS 74.7 ± 18.4), (42.1 ± 0.9 VS 58.3 ± 16.5) and (25.2 ± 6.1VS 30 ± 8.1) respectively and p-value of<0.001, 0.002 and 0.05 respectively. However at 24 hrs there was no significant difference in VAS with mean VAS scales of 22.6 ± 4.5 VS 23.6 ± 4.9 and p-value of 0.49. The dose of infused Morphine during 24 hrs was significantly less in the magnesium sulphate group than the placebo group with the means of 4.36 ± 1.4 VS 7.02 ± 1.9 mg respectively (p<0.001).
Conclusion: Administration of bolus 50 mg/kg magnesium sulphate prior to induction of general anesthesia may significantly decreased the morphine requirement during immediate post operative period and can be recommended as one of the modalities of post-operative pain control in the pregnant patients.

 
Keyword(s): MAGNESIUM SULFATE, OPIOID, CESAREAN, PAIN, GENERAL ANESTHESIA
 
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