Paper Information

Journal:   PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)   WINTER 2016 , Volume 13 , Number 4; Page(s) 57 To 62.
 
Paper: 

THE EFFECT OF EIGHT WEEKS OF ENDURANCE TRAINING ON THE HIPPOCAMPAL CONCENTRATION OF TUMOR NECROSIS FACTOR ALPHA IN FEMALE RATS WITH ALZHEIMER'S DISEASE

 
 
Author(s):  ZARE M., ZAR A., EDALATMANESH M.A.*
 
* DEPT. OF PHYSIOLOGY, ISLAMIC AZAD UNIVERSITY, SHIRAZ BRANCH, SHIRAZ, IRAN
 
Abstract: 

Introduction: Alzheimer's is a neuro-degenerative disease associated with a decline in memory abilities and brain changes that ultimately lead to dementia. The present study was conducted to investigate the effect of eight weeks of endurance training on the hippocampal concentration of tumor necrosis factor alpha (TNFa) in female rats with Alzheimer's disease.
Materials and Methods: A total of 30 female Sprague Dawley rats were randomly divided into a control group, a sham group and an endurance training group. Alzheimer's was induced to the rats through Methyltin Chloride. The endurance training group exercised on the treadmill for eight weeks. The hippocampal concentration of TNF
awas then measured in all the groups. The data obtained were analyzed using the two-way ANOVA and Tukey’s post-hoc test.
Results: The hippocampal concentration of TNF
awas significantly lower in the exercise group compared to the sham group. Methyltin chloride poisoning increased this concentration and endurance training reduced it in the rats (P£0.05).
Conclusion: Endurance training reduces the hippocampal concentrationof TNF
a in female rats with Alzheimer's disease.

 
Keyword(s): ALZHEIMER, TUMOR NECROSIS FACTOR ALPHA, MEMORY, HIPPOCAMPUS
 
References: 
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