Paper Information

Journal:   PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)   WINTER 2016 , Volume 13 , Number 4; Page(s) 47 To 55.
 
Paper: 

THE ANTIBACTERIAL EFFECTS OF THE NEW DERIVATIVES OF THIAZOLE, IMIDAZOLE AND TETRAHYDROPYRIDINE AGAINST PROTEUS VULGARIS: AN IN VITRO STUDY

 
 
Author(s):  GHASEMI B.*, BEYZAEI H., NAJIMI M.
 
* DEPT. OF PATHOBIOLOGY, FACULTY OF VETERINARY MEDICINE, UNIVERSITY OF ZABOL, ZABOL, IRAN
 
Abstract: 

Introduction: Proteus vulgaris is a major opportunistic hospital pathogen whose antibiotic resistance has recently become a challenging topic for researchers exploring the effect of new antibacterial compounds on this bacteria. Thiazole, Imidazole, and Tetrahydropyridine derivatives are new antibacterial compounds with confirmed inhibitory effects on many pathogenic bacteria. The present study examines the antibacterial effects of 15 new derivatives of Thiazole, Imidazole and Tetrahydropyridine on Proteus vulgaris.
Materials and Methods: Derivatives of Thiazole and Imidazole were first synthesized and prepared as DMSO solutions. To assess the antibacterial effects of the derivatives, the zone diameter of growth inhibition was measured using the disc diffusion method and the Minimum Inhibitory Concentration (MIC) was determined through a 96-well plate dilution.
Results: The results obtained showed that the 9a-g derivatives of Imidazole and Tetrahydropyridine and the 6ac, 10a and 10c derivatives of Thiazole had no inhibitory effects on Proteus vulgaris. The 6c, 9, and 10b derivatives of Thiazole had a zone diameter of growth inhibition of 1±0.2, 10.2±0.1 and 4.3±0.1 mm and a MIC of 128, 512 and 1024
mg/ml in Proteus vulgaris and were therefore found to have inhibitory effects against this pathogen.
Conclusion: The present study confirms the antibacterial effects of some new derivatives of Thiazole (6d, 9 and 10b) on standard strains of Proteus vulgaris. Further studies are required for assessing the effects of these compounds on treatment-resistant strains of Proteus vulgaris.

 
Keyword(s): ANTIBACTERIAL, THIAZOLES, IMIDAZOLES, P. VULGARIS
 
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