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Paper Information

Journal:   PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)   WINTER 2016 , Volume 13 , Number 4; Page(s) 23 To 32.
 
Paper: 

THE EFFECT OF THE METHANOL EXTRACT OF CAUCASIAN WHORTLEBERRY ON GLUCOSE, OXIDATIVE BIOMARKERS, CHOLESTEROL AND HDL IN DIABETIC MALE RATS

 
 
Author(s):  FIROUZEH M., SHAHANIPOUR K.*
 
* DEPT. OF BIOCHEMISTRY, ISLAMIC AZAD UNIVERSITY, FALAVARJAN BRANCH, ISFAHAN, IRAN
 
Abstract: 

Introduction: Vaccinium arctostaphylos is a medicinal plant used for the treatment of diabetes. The present study was conducted to investigate the effect of the methanol extract of Caucasian whortleberry on glucose, oxidative biomarkers, HDL and cholesterol.
Materials and methods: The present experimental study was conducted on 24 male Wistar rats divided into a healthy control group, a diabetic control group and two diabetic trial groups treated with 150 and 250 mg/kg of body weight doses of the methanol extract of Caucasian whortleberry. After inducing diabetes in the rats, the effect of 30 days of intraperitoneal injection of the extract was examined on their blood biochemical markers.
Results: Comparing the two diabetic trial groups treated with Caucasian whortleberry extract revealed the 250 mg/kg dose to be the most effective concentration for reducing glucose, increasing HDL, increasing paraxonase activity, reducing malondialdehyde and reducing body weight, while the 150mg/kg dose of the extract was the most effective for reducing cholesterol and protein carbonyl (P<0.05).
Conclusion: The present study showed that the methanol extract of Caucasian whortleberry can reduce the adverse effects of diabetes on many biochemical markers and thus boasts medicinal properties.

 
Keyword(s): GLUCOSE, CHOLESTEROL, MALONDIALDEHYDE, PROTEIN CARBONYL, PARAOXONASE
 
 
References: 
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APA: Copy

FIROUZEH, M., & SHAHANIPOUR, K. (2016). THE EFFECT OF THE METHANOL EXTRACT OF CAUCASIAN WHORTLEBERRY ON GLUCOSE, OXIDATIVE BIOMARKERS, CHOLESTEROL AND HDL IN DIABETIC MALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 13(4), 23-32. https://www.sid.ir/en/journal/ViewPaper.aspx?id=508355



Vancouver: Copy

FIROUZEH M., SHAHANIPOUR K.. THE EFFECT OF THE METHANOL EXTRACT OF CAUCASIAN WHORTLEBERRY ON GLUCOSE, OXIDATIVE BIOMARKERS, CHOLESTEROL AND HDL IN DIABETIC MALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL). 2016 [cited 2021May14];13(4):23-32. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=508355



IEEE: Copy

FIROUZEH, M., SHAHANIPOUR, K., 2016. THE EFFECT OF THE METHANOL EXTRACT OF CAUCASIAN WHORTLEBERRY ON GLUCOSE, OXIDATIVE BIOMARKERS, CHOLESTEROL AND HDL IN DIABETIC MALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), [online] 13(4), pp.23-32. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=508355.



 
 
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