Paper Information

Journal:   JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY   2015 , Volume - , Number 71; Page(s) 51 To 59.
 
Paper: 

STUDY OF STRAND BREAKS INDUCED BY DIRECT EFFECTS OF MONOENERGETIC ELECTRONS IN B CONFORMATION OF GENETIC MATERIAL OF LIVING CELLS BY USING GEANT4

 
 
Author(s):  SEMSARHA F., RAISALI G.R.*, GOLIAEI B., KHALAFI H.
 
* RADIATION APPLICATIONS RESEARCH SCHOOL, NUCLEAR SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE, AEOI, TEHRAN – IRAN
 
Abstract: 

In this study, DNA damage and statistics of hit in any compartments of B-DNA conformation of genetic material of living cells, induced by monoenergetic electrons, have been studied using Monte Carlo Geant4 (Geometry and tracking 4)-DNA toolkit. Simple 34 bp segments of B-DNA conformation, repeated randomly in high number, and monoenergetic electrons (1-20 keV) have been simulated in a volume of typical animal cell nucleus. The average yields of single strand and double strand damage for this energy range of electrons were 24.6 Gy-1Gbp-1 and 0.295 Gy-1Gbp-1, respectively. The highest hit efficiency is for phosphodiester volume of B-DNA model and the most single strand break damage yield has been calculated for 8 keV electrons. The averaged DSB to SSB fraction for this energy range electrons is about 0.031.

 
Keyword(s): MONOENERGETIC ELECTRONS, SINGLE STRAND BREAK, DOUBLE STRAND BREAK, VOLUME MODEL OF B-DNA, GEANT4
 
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