Paper Information

Journal:   JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH   DECEMBER 2014 , Volume 8 , Number 4; Page(s) 169 To 173.
 
Paper: 

ASSOCIATION BETWEEN ANGIOTENSINOGEN M235T POLYMORPHISM AND PREECLAMPSIA IN IRANIAN PREGNANT WOMEN

 
 
Author(s):  AFSHARIANI RAHA, ROOZBEH JAMSHID, SHARIFIAN MARYAM*, GHAEDI MAHBOBEH, SAMSAMI DEHAGHANI ALAMTAJ, GHADERI ABBAS
 
* DEPARTMENT OF NEUROLOGY, STUDENT RESEARCH COMMITTEE, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Objective: To determine the possible association between the M235T variant of angiotensinogen gene and preeclampsia in Iranian preeclamtic women with hypertension during pregnancy.
Materials and methods: During a case control study, we used polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analysis to investigate the association between M235T polymorphism in preeclamtic women compared to normotensive controls.
Results: The M235T polymorphism was significantly associated with increased preeclampsia risk in the studied population as supported by a p value of 0.017 and chi-square value of 8.12. The frequency of mutated allele and genotype distribution showed a significant difference between preeclamtic women and control groups.
Conclusion: The result indicates that the AGT M235T polymorphism plays a significant role in preeclampsia observed in selected Iranian preeclamtic women, and it can be considered as a major risk factor for preeclampsia.

 
Keyword(s): ANGIOTENSINOGEN M235T POLYMORPHISM, PREECLAMPSIA
 
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