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Paper Information

Journal:   IRANIAN JOURNAL OF VETERINARY RESEARCH (IJVR)   2016 , Volume 17 , Number 2 (55); Page(s) 134 To 136.
 
Paper: 

SCIENTIFIC REPORT: IMMUNOHISTOCHEMICAL CHARACTERIZATION OF SEBACEOUS EPITHELIOMA IN TWO DOGS

 
 
Author(s):  YOON J.S., PARK J.*
 
* DEPARTMENT OF VETERINARY INTERNAL MEDICINE, COLLEGE OF VETERINARY MEDICINE, CHONBUK NATIONAL UNIVERSITY, 567 BAEKJE-DAERO, DEOKJIN-GU, JEONJU, JEONBUK 561-756, KOREA
 
Abstract: 

This report describes two cases of sebaceous epithelioma and its immunohistochemical characterization with CK 14, CK18, p63, Ki67 and Bcl-2 immunostaining. Case 1 was a 12-year-old, intact English Cocker spaniel female presenting with multiple skin nodules over one year. Case 2 was a 7-year-old, spayed poodle female with a five-month history of solitary mass. Hematoxylin and eosin (H&E) staining showed that the nodules in both cases were irregular lobules comprised of epithelial cells around well- differentiated sebocytes. Neoplastic cells were positive for CK14 and p63 but were negative for CK18 cell marker. In addition, immunostaining for Ki67 proliferation marker showed 13.1% and 12.4% positive cells in the two cases, respectively. Furthermore, Bcl-2, which is highly expressed in human benign sebaceous tumors, was seen in basaloid cell nuclei and cytoplasm. CK14, CK18, p63, Ki67, and Bcl-2 antibody application provided further information for diagnosing sebaceous epithelioma and for prognosis in these two cases.

 
Keyword(s): BCL-2, CYTOKERATIN, DOG, IMMUNOHISTOCHEMISTRY, SEBACEOUS EPITHELIOMA
 
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