Paper Information

Journal:   RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)   MAY 2016 , Volume 11 , Number 3; Page(s) 259 To 264.
 
Paper: 

SHORT COMMUNICATION: FREQUENCY DISTRIBUTION OF POLYMORPHISMS OFCYP2C19, CYP2C9, VKORC1AND SLCO1B1 GENES IN THE YAKUT POPULATION

 
 
Author(s):  FILIPPOVICH VASILYEV FILIPP*, DANILOVA DIANA ALEKSANDROVNA, SERGEEVICH KAIMONOV VLADIMIR, CHERTOVSKIH YANA VALERIEVNA, MAKSIMOVA NADEZDA ROMANOVNA
 
* LIMITED LIABILITY COMPANY “GENEDIAG”, NORTH-EASTERN FEDERAL UNIVERSITY, YAKUTSK, RUSSIA
 
Abstract: 

Allele frequencies of single nucleotide polymorphisms (SNPs) are variable among different populations, therefore the study of SNPs in ethnic groups is important for establishing the clinical significance of the screening of these polymorphisms. The main goal of the research is to study the polymorphisms ofCYP2C9, CYP2C19, VKORC1, and SLCO1B1 in Yakuts. Genomic DNA from 229 Yakut subjects were analyzed by real-time polymerase chain reaction (PCR) (SLCO1B1+521T>C, VKORC1 -1639G>A, CYP2C19 +681G>A, +636G>A, CYP2C9+430?>T, +1075A>C). Genotype frequencies of polymorphisms in the population of the Yakuts were more characteristic of the Asian population. The results have been included in the software application “Lekgen” that we developed for the interpretation of pharmacogenetic testing. The data of our study obtained on frequency carriers of polymorphisms of genesSLCO1B1, ? YP2C19, CYP2C9, VKORC1among the Yakuts may be useful in developing recommendations for a personalized therapy.

 
Keyword(s): POLYMORPHISM, GENOTYPING, PHARMACOGENETICS, YAKUTS
 
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