Paper Information

Journal:   RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)   MAY 2016 , Volume 11 , Number 3; Page(s) 210 To 218.
 
Paper: 

SYNTHESIS AND CYTOTOXICITY EVALUATION OF SOME NEW 6-NITRO DERIVATIVES OF THIAZOLE-CONTAINING 4- (3H) –QUINAZOLINONE

 
 
Author(s):  HOSSEINZADEH LEILA, ALIABADI ALIREZA, KALANTARI MASOOD, MOSTAFAVI ABOLFAZL, RAHMANI KHAJOUEI MARZIEH*
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, SCHOOL OF PHARMACY AND PHARMACEUTICAL SCIENCE, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, I.R. IRAN
 
Abstract: 

Quinazolinones are a group of fused heterocyclic compounds which have valuable biological properties including cytotoxic, antibacterial and antifungal activities. Thiazole group-containing compounds have been also reported to have a wide range of biological activities such as antitumor, anti-inflammatory, analgesic and antibacterial effects. Due to valuable cytotoxic effects of both thiazole groups and quinazoline derivatives, in this study a series of quinazolinone-thiazole hybrids were synthesized and evaluated for their cytotoxic effects on three cell lines including MCF-7, HT-29, and PC-3. Among tested compounds (quinazolinones and three intermediates), k5 and k6 showed highest cytotoxic activities against PC3 cell line.
K6 and C were most active compounds against MCF7 and K6 showed best cytotoxicity on HT-29 cell line.

 
Keyword(s): QUINAZOLINONE, THIAZOLE, CYTOTOXICITY
 
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