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Paper Information

Journal:   RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)   MAY 2016 , Volume 11 , Number 3; Page(s) 187 To 199.
 
Paper: 

THEORETICAL DESIGN OF A NEW CHIMERIC PROTEIN FOR THE TREATMENT OF BREAST CANCER

 
 
Author(s):  SOLEIMANI MEYSAM, MAHNAM KARIM, MIRMOHAMMAD SADEGHI HAMID, SADEGHI ALIABADI HOJJAT, JAHANIAN NAJAFABADI ALI*
 
* DEPARTMENT OF PHARMACEUTICAL BIOTECHNOLOGY, SCHOOL OF PHARMACY AND PHARMACEUTICAL SCIENCES, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, I.R. IRAN
 
Abstract: 

p28 and NRC peptides are two anticancer peptides with various mechanisms have shown to be effective against breast cancer. Therefore, it seems that construction of a chimeric protein containing the two peptides might cause synergistic cytotoxic effects. However, since the two peptides bear opposite charges, production of a chimeric protein in which the two moieties do not intervene each other is difficult. In this study, our goal was to find a suitable peptide linker for the new chimeric protein in a manner that none of the peptides intervene the other’s function. We selected some linkers with different characteristics and lengths and created a small library of the chimeric proteins harboring these linkers. Homology modeling and molecular dynamic simulation revealed that (PA)5P and (EAAAK) 3 linkers can separate the p28 and NRC peptides effectively. Thus, the chimeric protein linked with (PA)5P or (EAAAK) 3 linkers might show synergistic and stronger anticancer effects than the separate peptide moieties because they could exert their cytotoxic effects freely which is not influenced by the other part.

 
Keyword(s): NRC, P28, LINKER, SALT BRIDGE, HOMOLOGY MODELING, MOLECULAR DYNAMIC SIMULATION
 
 
References: 
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Click to Cite.
APA: Copy

SOLEIMANI, M., & MAHNAM, K., & MIRMOHAMMAD SADEGHI, H., & SADEGHI ALIABADI, H., & JAHANIAN NAJAFABADI, A. (2016). THEORETICAL DESIGN OF A NEW CHIMERIC PROTEIN FOR THE TREATMENT OF BREAST CANCER. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 11(3), 187-199. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507713



Vancouver: Copy

SOLEIMANI MEYSAM, MAHNAM KARIM, MIRMOHAMMAD SADEGHI HAMID, SADEGHI ALIABADI HOJJAT, JAHANIAN NAJAFABADI ALI. THEORETICAL DESIGN OF A NEW CHIMERIC PROTEIN FOR THE TREATMENT OF BREAST CANCER. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS). 2016 [cited 2021May09];11(3):187-199. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507713



IEEE: Copy

SOLEIMANI, M., MAHNAM, K., MIRMOHAMMAD SADEGHI, H., SADEGHI ALIABADI, H., JAHANIAN NAJAFABADI, A., 2016. THEORETICAL DESIGN OF A NEW CHIMERIC PROTEIN FOR THE TREATMENT OF BREAST CANCER. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), [online] 11(3), pp.187-199. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507713.



 
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