Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   PHARMACEUTICAL SCIENCES   2012 , Volume 18 , Number 1; Page(s) 79 To 86.
 
Paper: 

STUDY OF THE CORRELATION BETWEEN THERMODYNAMIC PARAMETERS AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS

 
 
Author(s):  ZAKERI MILANI P., BARZRGAR JALALI M., JANATABADI E., MAJIDPOUR F., ISLAMBULCHILAR Z., VALIZADEH H.*
 
* FACULTY OF PHARMACY, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Objectives: This study was designed to investigate the correlation between thermodynamic parameters, ideal solubility and some pharmacokinetic parameters of the compounds.
Methods: For thermodynamics analysis, 5 mg of pure drug was weighed in a aluminum pan. Thermodynamic parameters were used for determination of ideal solubility. Correlation between ideal solubility and physicochemical and pharmacokinetic parameters was investigated.
Results: The results indicated that there is a linear correlation between ideal solubility and permeability with R=0.8. There are also meaningful correlation between ideal solubility and other physicochemical and pharmacokinetic parameters.
Conclusion: This investigation revealed that the ideal solubility could be an appropriate parameter for prediction of drugs pharmacokinetics.

 
Keyword(s): THERMODYNAMIC, IDEAL SOLUBILITY, PERMEABILITY, BIOPHARMACEUTICAL CLASSIFICATION SYSTEM
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

ZAKERI MILANI, P., & BARZRGAR JALALI, M., & JANATABADI, E., & MAJIDPOUR, F., & ISLAMBULCHILAR, Z., & VALIZADEH, H. (2012). STUDY OF THE CORRELATION BETWEEN THERMODYNAMIC PARAMETERS AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS. PHARMACEUTICAL SCIENCES, 18(1), 79-86. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507702



Vancouver: Copy

ZAKERI MILANI P., BARZRGAR JALALI M., JANATABADI E., MAJIDPOUR F., ISLAMBULCHILAR Z., VALIZADEH H.. STUDY OF THE CORRELATION BETWEEN THERMODYNAMIC PARAMETERS AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS. PHARMACEUTICAL SCIENCES. 2012 [cited 2021July25];18(1):79-86. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507702



IEEE: Copy

ZAKERI MILANI, P., BARZRGAR JALALI, M., JANATABADI, E., MAJIDPOUR, F., ISLAMBULCHILAR, Z., VALIZADEH, H., 2012. STUDY OF THE CORRELATION BETWEEN THERMODYNAMIC PARAMETERS AND SOME PHYSICOCHEMICAL AND PHARMACOKINETIC PARAMETERS. PHARMACEUTICAL SCIENCES, [online] 18(1), pp.79-86. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507702.



 
 
Yearly Visit 28
 
 
Latest on Blog
Enter SID Blog