Paper Information

Journal:   PHARMACEUTICAL SCIENCES   2012 , Volume 18 , Number 1; Page(s) 43 To 50.
 
Paper: 

EFFECT OF KEFIR CONSUMPTION ON SPATIAL LEARNING AND MEMORY CONSOLIDATION IN ADULT MALE RATS

 
 
Author(s):  HAGHPANAH T., SHEIBANI V., AFARINESH MOHAMMADREZA*
 
* SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE, FACULTY OF MEDICINE, TEHRAN, IRAN
 
Abstract: 

Objectives: Milk and its products have an important role in nutrition and health. Kefir, a probiotic product of milk, may have a modulator effect in memory potentially. The aim of this study was to investigate the effect of oral administration of kefir on the spatial learning and memory of male rat.
Methods: Forty two Wistar male rats weighting 275-300gr were used in this study. Animals were trained in Morris Water Maze task with 4 trails for 4 consecutive days and the retention of spatial training was evaluated 24h after the last training session. Kefir (25, 50, 75 and 100) % or saline was administrated orally in volume 10 ml/kg for four weeks by a gavage. The control group was intact (n=7).
Results: Comparing of the total distance and time of reaching to the hidden platform in MWM in the acquisition days has been showed a significant decrease between kefir administration and control groups (p<0.05). On the retrieval day, administration of kefir (25, 75 and 100) % increased the time of swimming in the trigger zone to find the platform, significantly (p<0.01, p<0.05 and p<0.05, respectively).
Conclusion: Oral administration of kefir can improve spatial learning and consolidation of memory in rat.

 
Keyword(s): KEFIR, SPATIAL LEARNING AND MEMORY, MORRIS WATER MAZE, RAT
 
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