Paper Information

Journal:   IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)   2016 , Volume 10 , Number 1; Page(s) 1 To 6.
 
Paper: 

PLASMA PHARMACOKINETICS AND MUSCLE DISPOSITION OF MARBOFLOXACIN IN CHICKENS

 
 
Author(s):  URZUA N., ERRECALDE C., PRIETO G.*, LUDERS C., PICCO E., PAULA TONINI M.
 
* DEPARTMENT OF PHARMACOLOGY, FACULTY OF AGRICULTURE AND VETERINARY, NATIONAL UNIVERSITY OF RIO CUARTO, RIO
 
Abstract: 

BACKGROUND: Reports on the pharmacokinetics of marbofloxacin in birds are scarce, even when it is a useful tool in poultry production.
OBJECTIVES: Determining marbofloxacin kinetic parameters in plasma and muscle arrangement after intravenous and oral administrations and establishing its withdrawal period.
METHODS: Clinical healthy chickens (1.08±0.22 kg) were used as experimental subjects, formed in groups of 5.
In Group A (n=45) birds received 2 mg/kg of marbofloxacin intravenously while group B (n=65) was given the same oral dose after fasting for 12 hours. Blood samples in the groups and 5 g of muscle were obtained at different times, in A group up to 24 hours and in B group until 120 hours after application.
Once the samples were obtained and treated, marbofloxacin was quantified by HPLC.
RESULTS: Marbofloxacin in fasted chickens is almost completely absorbed (F=97%), mean residence time is moderate (6.9 hours), with a high volume of distribution. Orally, mean residence time is less in plasma (4.9 hours) and the withdrawal time was calculated 2.5 days.
CONCLUSIONS: The kinetic results are consistent with those presented by other fluoroquinolones in poultry and are in line with short production cycles in chickens.

 
Keyword(s): CHICKENS, HPLC, MARBOFLOXACIN, PHARMACOKINETICS
 
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