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Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   MAY 2016 , Volume 11 , Number 2; Page(s) 0 To 0.
 
Paper: 

COMPARISON OF THE EIGHT-HOUR WITH THE 22-HOUR INFUSION OF 5-FLUOROURACIL, IN THE FOLFOX CHEMOTHERAPY OF COLON CANCER: A RETROSPECTIVE STUDY

 
 
Author(s):  SHAHBAZIAN HOJATOLLAH, RAZMJOO SASAN, ARVANDI SHOLE, HOSSEINI SEYED MOHAMMAD, HOSEINZADEH MEHRAN, DEILAMANI AHMAD AHMADZADEH, MOHAMADIAN FATEMEH*
 
* DEPARTMENT OF CLINICAL ONCOLOGY, GOLESTAN HOSPITAL, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, I.R. IRAN
 
Abstract: 

Background: The optimal protocol for administration of 5-fluorouracil (5-FU) in chemotherapy of colorectal cancer is unknown.
Objectives: Wecompared treatment outcomes of short-time infusion of 5-FU (8-hour infusion) with 22-hour infusion, in chemotherapy management of colorectal cancer.
Patients and Methods: A retrospective study was conducted on colon cancer patients, who have been treated for at least 24 weeks with the FOLFOX regimen (5-FU, leucovorin, and oxaliplatin). Patients who had received infusion of 5-FU, either over 8 hours (5-FU 8h) or over 22 hours (5-FU 22h) were selected. The study endpoints were 3 and 5 years disease free survival and overall survival.
Results: A total of 58 patients, in the 5-FU 8h, and 50 patients, in the 5-FU 22h groups, were studied. Based on the intention-to-treat analysis, there was a lower overall mortality (44% vs.22.4%, P=0.023) and lower overall relapse (46% vs.18.9%, P=0.004), as well as a higher 3 years disease free survival (81% vs.58%, P=0.011) in the 5-FU 8h, compared with 5-FU 22h group. The Log Rank test showed a difference between the two groups, for disease free survival (P=0.008), as well as overall survival (P=0.014), confirmed by Cox Regression analysis: hazard ratio [95% CI] =0.365 [0.160 to 0.833] and 0.286 [0.100 to 0.817], respectively.
Conclusions: We found better outcomes for the colon cancer patients, who had received infusion of 5-FU 8h, compared with 5-FU 22h, in the FOLFOX chemotherapy. These findings should be tested in prospective clinical trials.

 
Keyword(s): FLUOROURACIL, FOLFOX PROTOCOL, CHEMOTHERAPY, COLORECTAL NEOPLASMS
 
 
References: 
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APA: Copy

SHAHBAZIAN, H., & RAZMJOO, S., & ARVANDI, S., & HOSSEINI, S., & HOSEINZADEH, M., & DEILAMANI, A., & MOHAMADIAN, F. (2016). COMPARISON OF THE EIGHT-HOUR WITH THE 22-HOUR INFUSION OF 5-FLUOROURACIL, IN THE FOLFOX CHEMOTHERAPY OF COLON CANCER: A RETROSPECTIVE STUDY. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 11(2), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507622



Vancouver: Copy

SHAHBAZIAN HOJATOLLAH, RAZMJOO SASAN, ARVANDI SHOLE, HOSSEINI SEYED MOHAMMAD, HOSEINZADEH MEHRAN, DEILAMANI AHMAD AHMADZADEH, MOHAMADIAN FATEMEH. COMPARISON OF THE EIGHT-HOUR WITH THE 22-HOUR INFUSION OF 5-FLUOROURACIL, IN THE FOLFOX CHEMOTHERAPY OF COLON CANCER: A RETROSPECTIVE STUDY. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS. 2016 [cited 2021July31];11(2):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507622



IEEE: Copy

SHAHBAZIAN, H., RAZMJOO, S., ARVANDI, S., HOSSEINI, S., HOSEINZADEH, M., DEILAMANI, A., MOHAMADIAN, F., 2016. COMPARISON OF THE EIGHT-HOUR WITH THE 22-HOUR INFUSION OF 5-FLUOROURACIL, IN THE FOLFOX CHEMOTHERAPY OF COLON CANCER: A RETROSPECTIVE STUDY. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, [online] 11(2), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507622.



 
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