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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   MAY 2016 , Volume 11 , Number 2; Page(s) 0 To 0.
 
Paper: 

ANTINOCICEPTIVE EFFECT OF THE ENDEMIC SPECIESNEPETA DEPAUPERATA BENTH

 
 
Author(s):  MOUSAVI ZAHRA*, HOSAINI ATIEH SADAT, ASGARPANAH JINOUS, NAJAFIZADEH PARVANEH
 
* DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, FACULTY OF PHARMACY, PHARMACEUTICAL SCIENCES BRANCH, ISLAMIC AZAD UNIVERSITY, TEHRAN, I.R. IRAN
 
Abstract: 

Background: Nepeta depauperata Benth is an endemic species and is extensively exploited as an anti-inflammatory agent in Iranian traditional medicine.
Objectives: This study was designed to evaluate the antinociceptive activity of methanol extract of N. depauperata in male mice.
Materials and Methods: The anti-nociceptive activities of the extract were investigated by the formalin test and Hot plate test respectively. Comparisons between the groups were carried out using one-way analysis of variance (ANOVA), and post Hoc Tukey test.
Results: N. depauperata extract showed anti-nociceptive effect. Doses of 50, 100 and 200 mg/kg reduced the paw flexing time in formalin test from the control (P<0.05 in both phases). The doses of 25, 50, 100 and 200 mg/kg; 100 and 200 mg/kg reduced the pawlicking time in first and second phases of the formalin test from the control, respectively (P<0.05). The observed effect was not reversed by naloxone. In Hot plate test, doses of 160 and 250 mg/kg significantly reduced the nociception in comparisons to control (P<0.05). All doses of the studied extract also showed antinociceptive activity.
Conclusions: This study revealed that the methanol extract of N.depauperata may minimize both the acute and chronic forms of nociception and may have potent role against inflammation.

 
Keyword(s): ANTI-NOCICEPTION, ANALGESICS, NEPETA DEPAUPERATA
 
 
References: 
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Click to Cite.
APA: Copy

MOUSAVI, Z., & HOSAINI, A., & ASGARPANAH, J., & NAJAFIZADEH, P. (2016). ANTINOCICEPTIVE EFFECT OF THE ENDEMIC SPECIESNEPETA DEPAUPERATA BENTH. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 11(2), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507596



Vancouver: Copy

MOUSAVI ZAHRA, HOSAINI ATIEH SADAT, ASGARPANAH JINOUS, NAJAFIZADEH PARVANEH. ANTINOCICEPTIVE EFFECT OF THE ENDEMIC SPECIESNEPETA DEPAUPERATA BENTH. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS. 2016 [cited 2021May10];11(2):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507596



IEEE: Copy

MOUSAVI, Z., HOSAINI, A., ASGARPANAH, J., NAJAFIZADEH, P., 2016. ANTINOCICEPTIVE EFFECT OF THE ENDEMIC SPECIESNEPETA DEPAUPERATA BENTH. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, [online] 11(2), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507596.



 
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