Paper Information

Journal:   JOURNAL OF OPHTHALMIC AND VISION RESEARCH   2014 , Volume 9 , Number 3; Page(s) 350 To 361.
 
Paper: 

BIRDSHOT RETINOCHOROIDOPATHY (REVIEW ARTICLE)

 
 
Author(s):  VITALE ALBERT T.*
 
* DEPARTMENT OF OPHTHALMOLOGY AND VISUAL SCIENCES, JOHN A. MORAN EYE CENTER, 65 N. MARIO CAPECCHI DRIVE, SALT LAKE CITY, UT 84132, U.S.A.
 
Abstract: 

Birdshot retinochoroidopathy (BSRC) is an uncommon, but well-characterized chronic, bilateral posterior uveitis, which is uniquely associated with the human leukocyte antigen-A29 phenotype. The disease presents predominantly in middle-aged Caucasian females who complain of blurred vision, floaters, photopsias, paracentral scotomas and nyctalopia. While autoimmune mechanisms are thought to play an important role in the pathogenesis of BSRC, its etiology remains unknown. Important questions remain in our understanding of BSRC with respect to its pathogenesis, epidemiology, optimal treatment, and prognosis, including the determinants of remission and relapse, as well as the best strategy for monitoring disease activity, progression and response to therapy with electroretinographic and psychophysical testing, established and emerging imaging modalities, and peripheral cytokines profiles.

 
Keyword(s): IMMUNOMODULATORY THERAPY, MONITORING, MULTI-MODAL IMAGING, PATHOGENESIS
 
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