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Paper Information

Journal:   JOURNAL OF OPHTHALMIC AND VISION RESEARCH   2014 , Volume 9 , Number 3; Page(s) 339 To 342.
 
Paper: 

THE EFFECT OF SYSTEMIC AMANTADINE SULFATE ON MALONDIALDEHYDE AND TOTAL THIOL LEVELS IN RAT CORNEAS

 
DOI: 

10.4103/2008-322X.143373

 
Author(s):  YALNIZ AKKAYA ZULEYHA*, FIDANCI VILDAN, KILINC AYTUL, BURCU AYSE, UNEY GUNER O., ORNEK FIRDEVS
 
* YUKARIOVECLER MAH, 1238 CAD, 12/22, CANKAYA, TR06520 ANKARA, TURKEY
 
Abstract: 

Purpose: To evaluate the malondialdehyde (MDA) and total thiol (sulfhydryl, SH) levels in rat corneas after intraperitoneal injection of amantadine sulfate.
Methods: A total of 12 Wistar albino rats were divided into two groups: control group (n=6) and amantadine group (n=6). Balanced salt solution (1 mL, 0.9% NaCl, twice/day) was injected into rats in control group.
Amantadine sulfate (2 mg/1 mL, twice/day) was injected into rats in amantadine group. In each group, two rats were injected for 1 week, two received injections for 1 month, and two rats received injections for 3 months. The corneas were homogenized and MDA and SH levels were measured spectroflourometrically.
Results: In control group, median MDA and SH levels were 2.37 (range, 0.92-3.60) and 25.35 (range, 6.30-54.0) nmol/mg, respectively. In amantadine group, median MDA and SH levels were 3.57 (range, 1.25-5.92) and 32.65 (range, 3.30-48.3) nmol/mg, respectively. The difference between this two groups regarding MDA (P=0.14) and SH (P=1.0) levels was statistically insignificant.
Conclusion: Systemically administered amantadine sulfate seems not to cause MDA and SH imbalance in rat corneas.

 
Keyword(s): AMANTADIN SULFATE, ANTI OXIDANT, CORNEA, MALONDYALDEHIDE, OXIDANT, RATS, TOTAL THIOL
 
 
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Click to Cite.
APA: Copy

YALNIZ AKKAYA, Z., & FIDANCI, V., & KILINC, A., & BURCU, A., & UNEY, G., & ORNEK, F. (2014). THE EFFECT OF SYSTEMIC AMANTADINE SULFATE ON MALONDIALDEHYDE AND TOTAL THIOL LEVELS IN RAT CORNEAS. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 9(3), 339-342. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507547



Vancouver: Copy

YALNIZ AKKAYA ZULEYHA, FIDANCI VILDAN, KILINC AYTUL, BURCU AYSE, UNEY GUNER O., ORNEK FIRDEVS. THE EFFECT OF SYSTEMIC AMANTADINE SULFATE ON MALONDIALDEHYDE AND TOTAL THIOL LEVELS IN RAT CORNEAS. JOURNAL OF OPHTHALMIC AND VISION RESEARCH. 2014 [cited 2021May13];9(3):339-342. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507547



IEEE: Copy

YALNIZ AKKAYA, Z., FIDANCI, V., KILINC, A., BURCU, A., UNEY, G., ORNEK, F., 2014. THE EFFECT OF SYSTEMIC AMANTADINE SULFATE ON MALONDIALDEHYDE AND TOTAL THIOL LEVELS IN RAT CORNEAS. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, [online] 9(3), pp.339-342. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507547.



 
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