Paper Information

Journal:   JOURNAL OF APPLIED MICROBIOLOGY IN FOOD INDUSTRY   SPRING 2016 , Volume 2 , Number 1; Page(s) 51 To 62.
 
Paper: 

INVESTIGATION THE EFFECT OF LACTOBACILLUS CASEI TD2 ON THYROID HORMONES (T3 AND T4) IN MALE WISTAR RATS UNDER CHRONIC RESTRAINT CONDITION

 
 
Author(s): 
 
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Abstract: 

The thyroid gland is one of the largest endocrine glands in the body, which is located in the anterior neck and consists of two connected lobes. The thyroid gland produces and secretes thyroid hormones, the principal ones being thyroxine (T4) and triiodothyronine (T3), which is more active. These hormones control rate of use of energy sources, protein synthesis, and controls the body's sensitivity to other hormones, growth and rate of function of many other systems in the body. Hence, the control of these hormones is pretty critical in body and it can be affected by too many factors such as stress. The effect of stress on thyroid function is complex. However, changes induced by stress on the serotonergic system, which is part of brain function, and cortisol levels may affect thyroid hormones metabolism. Probiotics are alive microorganisms when administrated which confer health benefit on consumers when in adequate amount. Use of probiotics can control the thyroid hormones by controlling the stress conditions. We use 40 male wistar rats with the same age and weight in this experiments. After 2 weeks of adaptation, the rats were randomly divided in to 4 groups (n=10). Control groups daily gavaged with 1 ml of PBS buffer (pH: 7.2), while the positive control restrained 15 min in restrainer for induction of Chronic restraint stress (CRS). The trail groups received 109 cfu of Lactobacillus case TD2 as probiotic by intra gastric gavage, while the Trail 2 group was CRS condition. After 3 weeks, rats were anaesthetized by inhalation of diethyl ether and blood samples were taken directly from their hearts. Then the level of thyroid hormones and glucose were assayed in blood serum. The results showed that the applied stress condition had no effect on T3 concentration level (p value=0.575). T4 level significantly decreased in positive control group compare to negative control (p value=0.001). Administration of probiotic increased the level of T4 to normal level and there was no significant difference between negative control and trial groups (p value=0.824). Stress caused significant increase in glucose level in positive control compare to negative control group (p value=0.0035). in trail groups the glucose concentrations were normal by use of probiotic (p value=0.9). The results of this experiment showed the L. casei TD2 could control the changes in thyroid hormones possiblt by control the CRS condition.

 
Keyword(s): STRESS, PROBIOTIC, T3, T4, THYROID HORMONES, L. CASEI TD2
 
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