Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   APRIL 2016 , Volume 7 , Number 2; Page(s) 137 To 142.
 
Paper: 

ELEVATED IL-17 AND TGF-β SERUM LEVELS: A POSITIVE CORRELATION BETWEEN T-HELPER 17 CELL-RELATED PRO-INFLAMMATORY RESPONSES WITH MAJOR DEPRESSIVE DISORDER

 
 
Author(s):  DAVAMI MOHAMMAD HASAN, BAHARLOU RASOUL*, AHMADI VASMEHJANI ABBAS, GHANIZADEH AHMAD, KESHTKAR MITRA, DEZHKAM IMAN, ATASHZAR MOHAMMAD REZA
 
* DEPARTMENT OF IMMUNOLOGY AND MICROBIOLOGY, SCHOOL OF MEDICINE, JAHROM UNIVERSITY OF MEDICAL SCIENCES, JAHROM, IRAN
 
Abstract: 

Introduction: Depression is a mental disorder that highly associated with immune system.
Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor
b (TGF- b) between patients with major depressive disorder and healthy controls.
Methods: Blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls with no history of malignancies or autoimmune disorders. The subjects were interviewed face to face according to DSM-IV diagnostic criteria. Depression score was measured using completed Beck Depression Inventory in both groups. The serum concentrations of IL-21, IL-17, and TGF-? were assessed using ELISA.
Results: The mean score of Beck Depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. IL-17 serum concentrations in the patients and the control group were 10.03±0.6 and 7.6±0.6 pg/mL, respectively (P=0.0002). TGF-? level in the patients group was significantly higher than compare to the control group; 336.7±20.19 vs.174.8±27.20 pg/mL, (P<0.0001). However, the level of IL-21 was not statistically different between the two groups 84.30±4.57 vs.84.12±4.15 pg/mL (P>0.05).
Conclusion: Considering pro-inflammatory cytokines, current results support the association of inflammatory response and depressive disorder. So, it seems that pro-inflammatory factors profile can be used as indicator in following of depression progress and its treatment impacts.

 
Keyword(s): MAJOR DEPRESSIVE DISORDER, INTERLEUKIN-17, INTERLEUKIN-21, TRANSFORMING GROWTH FACTOR-BETA, INFLAMMATORY RESPONSE
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 73
 
Latest on Blog
Enter SID Blog