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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)   MAY 2016 , Volume 9 , Number 5; Page(s) 0 To 0.
 
Paper: 

COMPARISON OF NEWLY ASSEMBLED FULL LENGTH HIV-1 INTEGRASE WITH PROTOTYPE FOAMY VIRUS INTEGRASE: STRUCTURE-FUNCTION PROSPECTIVE

 
 
Author(s):  DAYER MOHAMMAD REZA*
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, SHAHID CHAMRAN UNIVERSITY, AHVAZ, IR IRAN
 
Abstract: 

Background: Drug design against human immunodeficiency virus type 1 (HIV-1) integrase through its mechanistic study is of great interest in the area in biological research. The main obstacle in this area is the absence of the full-length crystal structure for HIV-1 integrase to be used as a model. A complete structure, similar to HIV-1 of a prototype foamy virus integrase in complex with DNA, including all conservative residues, is available and has been extensively used in recent investigations.
Objectives: The aim of this study was to determine whether the above model is precisely representative of HIV-1 integrase. This would critically determine the success of any designed drug using the model in deactivation of integrase and AIDS treatment.
Materials and Methods: Primarily, a new structure for HIV-1 was constructed, using a crystal structure of prototype foamy virus as the starting structure. The constructed structure of HIV-1 integrase was simultaneously simulated with a prototype foamy virus integrase on a separate occasion.
Results: Our results indicate that the HIV-1 system behaves differently from the prototype foamy virus in terms of folding, hydration, hydrophobicity of binding site and stability.
Conclusions: Based on our findings, we can conclude that HIV-1 integrase is vastly different from the prototype foamy virus integrase and does not resemble it, and the modeling output of the prototype foamy virus simulations could not be simply generalized to HIV-1 integrase. Therefore, our HIV-1 model seems to be more representative and more useful for future research.

 
Keyword(s): HUMAN IMMUNODEFICIENCY VIRUS TYPE-1, INTEGRASE, PROTOTYPE FOAMY VIRUS, MOLECULAR DYNAMIC SIMULATION
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

DAYER, M. (2016). COMPARISON OF NEWLY ASSEMBLED FULL LENGTH HIV-1 INTEGRASE WITH PROTOTYPE FOAMY VIRUS INTEGRASE: STRUCTURE-FUNCTION PROSPECTIVE. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(5), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507401



Vancouver: Copy

DAYER MOHAMMAD REZA. COMPARISON OF NEWLY ASSEMBLED FULL LENGTH HIV-1 INTEGRASE WITH PROTOTYPE FOAMY VIRUS INTEGRASE: STRUCTURE-FUNCTION PROSPECTIVE. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM). 2016 [cited 2021August03];9(5):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507401



IEEE: Copy

DAYER, M., 2016. COMPARISON OF NEWLY ASSEMBLED FULL LENGTH HIV-1 INTEGRASE WITH PROTOTYPE FOAMY VIRUS INTEGRASE: STRUCTURE-FUNCTION PROSPECTIVE. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), [online] 9(5), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507401.



 
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