Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   APRIL 2016 , Volume 7 , Number 2; Page(s) 97 To 106.
 
Paper: 

EFFECT OF GALLIC ACID ON DEMENTIA TYPE OF ALZHEIMER DISEASE IN RATS: ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES

 
DOI: 

10.15412/J.BCN.03070203

 
Author(s):  HAJIPOUR SOMAYEH, SARKAKI ALIREZA, FARBOOD YAGHOOB, EIDI AKRAM, MORTAZAVI PEJMAN, VALIZADEH ZOHREH*
 
* DEPARTMENT OF NURSING AND MIDWIFERY, DEZFOUL BRANCH, ISLAMIC AZAD UNIVERSITY, DEZFOUL, IRAN
 
Abstract: 

Introduction: To study the effect of gallic acid (GA) on hippocampal long-term potentiation (LTP) and histological changes in animal model of Alzheimer disease (AD) induced by beta-amyloid (Ab).
Methods: Sixty-four adult male Wistar rats (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, A
b (1?g/mL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP).
Results: Data showed that LTP amplitude and area under curve significantly impaired in AD rats (P<0.001), while significantly improved in AD rats treated with GA (P<0.05, P<0.01).
Conclusion: Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of A
b but with no effect on healthy rats.

 
Keyword(s): ALZHEIMER DISEASE, BETA-AMYLOID, LONG-TERM POTENTIATION, NEURONAL APOPTOSIS, RAT
 
 
References: 
  • ندارد
  •  
 
Click to Cite.
APA: Copy

HAJIPOUR, S., & SARKAKI, A., & FARBOOD, Y., & EIDI, A., & MORTAZAVI, P., & VALIZADEH, Z. (2016). EFFECT OF GALLIC ACID ON DEMENTIA TYPE OF ALZHEIMER DISEASE IN RATS: ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES. BASIC AND CLINICAL NEUROSCIENCE, 7(2), 97-106. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507390



Vancouver: Copy

HAJIPOUR SOMAYEH, SARKAKI ALIREZA, FARBOOD YAGHOOB, EIDI AKRAM, MORTAZAVI PEJMAN, VALIZADEH ZOHREH. EFFECT OF GALLIC ACID ON DEMENTIA TYPE OF ALZHEIMER DISEASE IN RATS: ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES. BASIC AND CLINICAL NEUROSCIENCE. 2016 [cited 2021May14];7(2):97-106. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507390



IEEE: Copy

HAJIPOUR, S., SARKAKI, A., FARBOOD, Y., EIDI, A., MORTAZAVI, P., VALIZADEH, Z., 2016. EFFECT OF GALLIC ACID ON DEMENTIA TYPE OF ALZHEIMER DISEASE IN RATS: ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES. BASIC AND CLINICAL NEUROSCIENCE, [online] 7(2), pp.97-106. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507390.



 
  pdf-File
Yearly Visit 86
 
Latest on Blog
Enter SID Blog