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Paper Information

Journal:   REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY   APRIL 2016 , Volume 4 , Number 2; Page(s) 76 To 81.
 
Paper: 

SHORT ARTICLE: COMPARATIVE IN SILICO STUDY OF SEX-DETERMINING REGION Y (SRY) PROTEIN SEQUENCES INVOLVED IN SEX-DETERMINING

 
 
Author(s):  VAKILI AZGHANDI MASOUME, NASIRI MOHAMMAD REZA*, SHAMSA ALI, JALALI MOHSEN, SHARIATI MOHAMMAD MAHDI
 
* DEPARTMENT OF ANIMAL SCIENCES, FACULTY OF AGRICULTURE, FERDOWSI UNIVERSITY OF MASHHAD, MASHHAD, IRAN
 
Abstract: 

Background: The SRY gene (SRY) provides instructions for making a transcription factor called the sex-determining region Y protein. The sex-determining region Y protein causes a fetus to develop as a male. In this study, SRY of 15 spices included of human, chimpanzee, dog, pig, rat, cattle, buffalo, goat, sheep, horse, zebra, frog, urial, dolphin and killer whale were used for determine of bioinformatic differences.
Methods: Nucleotide sequences of SRY were retrieved from the NCBI databank. Bioinformatic analysis of SRY is done by CLC Main Workbench version 5.5 and ClustalW (http: /www.ebi.ac.uk/clustalw/) and MEGA6 softwares.
Results: The multiple sequence alignment results indicated that SRY protein sequences from Orcinus orca (killer whale) and Tursiopsaduncus (dolphin) have least genetic distance of 0.33 in these 15 species and are 99.67% identical at the amino acid level. Homosapiens and Pantroglodytes (chimpanzee) have the next lowest genetic distance of 1.35 and are 98.65% identical at the amino acid level.
Conclusion: These findings indicate that the SRY proteins are conserved in the 15 species, and their evolutionary relationships are similar.

 
Keyword(s): BIOINFORMATICS ANALYSIS, SRY GENE, PHYLOGENY
 
 
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Click to Cite.
APA: Copy

VAKILI AZGHANDI, M., & NASIRI, M., & SHAMSA, A., & JALALI, M., & SHARIATI, M. (2016). SHORT ARTICLE: COMPARATIVE IN SILICO STUDY OF SEX-DETERMINING REGION Y (SRY) PROTEIN SEQUENCES INVOLVED IN SEX-DETERMINING. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 4(2), 76-81. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507353



Vancouver: Copy

VAKILI AZGHANDI MASOUME, NASIRI MOHAMMAD REZA, SHAMSA ALI, JALALI MOHSEN, SHARIATI MOHAMMAD MAHDI. SHORT ARTICLE: COMPARATIVE IN SILICO STUDY OF SEX-DETERMINING REGION Y (SRY) PROTEIN SEQUENCES INVOLVED IN SEX-DETERMINING. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2016 [cited 2021May08];4(2):76-81. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507353



IEEE: Copy

VAKILI AZGHANDI, M., NASIRI, M., SHAMSA, A., JALALI, M., SHARIATI, M., 2016. SHORT ARTICLE: COMPARATIVE IN SILICO STUDY OF SEX-DETERMINING REGION Y (SRY) PROTEIN SEQUENCES INVOLVED IN SEX-DETERMINING. REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, [online] 4(2), pp.76-81. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507353.



 
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