Paper Information

Journal:   JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)   APRIL 2016 , Volume 9 , Number 4; Page(s) 0 To 0.
 
Paper: 

THE ASSOCIATION OF HIGH RISK HUMAN PAPILLOMAVIRUSES IN PATIENTS WITH CERVICAL CANCER: AN EVIDENCE BASED STUDY ON PATIENTS WITH SQUAMOUS CELL DYSPLASIA OR CARCINOMA FOR EVALUATION OF 23 HUMAN PAPILLOMA VIRUS GENOTYPES

 
 
Author(s):  PIROOZMAND AHMAD, MOSTAFAVI ZADEH SEYED MOSTAFA, MADANI AZITA, SOLEIMANI REZA, NEDAEINIA REZA, NIAKAN MOHAMMAD*, AVAN AMIR, MANEIAN MOSTAFA, MORADI MOHAMMAD, EFTEKHAR ZAHRA
 
* DEPARTMENT OF MICROBIOLOGY, SHAHED UNIVERSITY, 31-ABDOLAZADEH ST., KESHAVARZ BLVD., POSTAL CODE: 1415635111, TEHRAN, IR IRAN
 
Abstract: 

Background: Cervical cancer is one of the leading causes of cancer-related death in females. Human papilloma virus (HPV) is the major risk factor of cervical cancer.
Objectives: The aim of the current study was to explore the frequency and role of 23 different HPVs in patients with cervical cancer.
Materials and Methods: Overall, 117 formalin-fix and paraffin-embedded (FFPE) tissues from cervical cancer patients with squamous cell carcinoma (SCC) or dysplasia were collected from Mirza-Kochakkhan-Jangali hospital, Tehran, Iran during year 2013, to investigate the presence of HPV- HPV- 67, 68, 6, 11, 13, 16, 17, 30, 69, 39, 40, 42, 64, 66 and 51 to 59 genotypes.
Results: The Pap smear report illustrated the presence of malignancy in 71 cases, while 11 cases had no evidence of malignancy. Among the patients, 26 cases had sexually transmitted disease with relative frequency of 0.58. Infection with papilloma virus was observed in 83.6% of SCC patients and 45% of the dysplasia group. The most prevalent HPV genotypes were 18 with 31.62% and 16 with 27.35% of cases. Moreover the relative frequencies of HPV-33, -6, -58, -52, -35 and -51, genotypes were 15.38, 7.69, 5.98, 5.12 and 3.41%, respectively. Among the different genotypes of HPV, 31 had the lowest and 16 had the highest relative frequency.
Conclusions: Our findings demonstrate that HPV-16 and -18 have a higher prevalence in our population than 31 and 51. Further investigations are required to evaluate the role of these genotypes in a larger multicenter setting for establishing their values for early detection of patients, which is useful for screening and vaccination programs of cancerous and precancerous lesions of cervical cancer.

 
Keyword(s): PAPILLOMA VIRUS, CERVICAL CANCER, HPV-16, HPV-18, POLYMERASE CHAIN REACTION
 
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