Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   JULY 2016 , Volume 7 , Number 3; Page(s) 259 To 267.
 
Paper: 

THE EFFECTS OF INFLAMMATORY TOOTH PAIN ON ANXIETY IN ADULT MALE RATS

 
DOI: 

10.15412/J.BCN.03070311

 
Author(s):  RAOOF MARYAM, EBRAHIMNEJAD HAMED*, ABBASNEJAD MEHDI, AMIRKHOSRAVI LADAN, RAOOF RAMIN, ESMAEILI MAHANI SAEED, RAMAZANI MOHSEN, SHOKOUHINEJAD NOUSHIN, KHOSHKHOUNEJAD MEHRFAM
 
* DEPARTMENT OF ORAL AND MAXILLOFACIAL RADIOLOGY, FACULTY OF DENTISTRY, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Introduction: This study aimed to examine the effects of induced inflammatory tooth pain on anxiety level in adult male rats.
Methods: The mandibular incisors of 56 adult male rats were cut off and prefabricated crowns were fixed on the teeth. Formalin and capsaicin were injected intradentally to induce inflammatory tooth pain. Diazepam treated group received diazepam 30 minutes before intradental injection. The anxiety-related behavior was evaluated with elevated plus maze test.
Results: Intradental application of chemical noxious stimuli, capsaicin and formalin, significantly affected nociceptive behaviors (P<0.001). Capsaicin (P<0.001) and formalin (P<0.01) significantly increased the anxiety levels in rats by decrease in the duration of time spent in open arm and increase in the duration of time spent in closed arm. Rats that received capsaicin made fewer open arm entries compared to the control animals (P<0.05). Capsaicin (P<0.001) and formalin (P<0.01) treated rats showed more stretch attend postures compared to the control and sham operated animals. In diazepam-pretreated rats, capsaicin induced algesic effect was prevented (P<0.001).
Conclusion: Inflammatory pulpal pain has anxiogenic effect on rats, whereas diazepam premedication showed both anxiolytic and pain reducing effects.

 
Keyword(s): ODONTALGIA, CAPSAICIN, FORMALIN, DIAZEPAM, ANXIETY, ELEVATED PLUS MAZE
 
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