Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   JULY 2016 , Volume 7 , Number 3; Page(s) 213 To 219.
 
Paper: 

EFFECTS OF DIMETHYL SULFOXIDE ON NEURONAL RESPONSE CHARACTERISTICS IN DEEP LAYERS OF RAT BARREL CORTEX

 
DOI: 

10.15412/J.BCN.03070306

 
Author(s):  SOLTANI NARJES, MOHAMMADI ELHAM, ALLAHTAVAKOLI MOHAMMAD, SHAMSIZADEH ALI*, ROOHBAKHSH ALI, HAGHPARAST ABBAS
 
* PHYSIOLOGY-PHARMACOLOGY RESEARCH CENTER, RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES, RAFSANJAN, IRAN
 
Abstract: 

Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for water-insoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200–1500 ?m depth) of the rat barrel cortex.
Methods: DMSO solution was prepared in 10% v/v concentration and injected into the lateral ventricle of rats. Neuronal spontaneous activity and neuronal responses to deflection of the principal whisker (PW) and adjacent whisker (AW) were recorded in barrel cortex. A condition test ratio (CTR) was used to measure inhibitory receptive fields in barrel cortex.
Results: The results showed that both PW and AW evoked ON and OFF responses, neuronal spontaneous activity and inhibitory receptive fields did not change following ICV administration of DMSO.
Conclusion: Results of this study suggest that acute ICV administration of 10% DMSO did not modulate the electrophysiological characteristics of neurons in the l deep ayers of rat barrel cortex.

 
Keyword(s): DMSO, ELECTROPHYSIOLOGY, SOMATOSENSORY CORTEX, RATS
 
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