Paper Information

Journal:   JOURNAL OF OPHTHALMIC AND VISION RESEARCH   2014 , Volume 9 , Number 4; Page(s) 423 To 426.
 
Paper: 

TOPICAL INTERFERON ALPHA?2B FOR TREATMENT OF NONINVASIVE OCULAR SURFACE SQUAMOUS NEOPLASIA WITH 360OLIMBAL INVOLVEMENT

 
 
Author(s):  ZAREI GHANAVATI SIAMAK*, ALIZADEH REZA, DENG SOPHIE X.
 
* EYE RESEARCH CENTER, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, KHATAM?AL?ANBIA EYE HOSPITAL, ABOOTALEB BLVD., MASHHAD, IRAN
 
Abstract: 

Purpose: To report the results of topical interferon alpha?2b (IFNa2b) for the treatment of ocular surface squamous neoplasia (OSSN) with 360o limbal involvement.
Methods: In a prospective observational study, five patients with biopsy proven primary or recurrent OSSN with 360o limbal involvement received topical IFN
a2b (3 million IU/ml, 4 times daily) and were followed from 8 to 12 months. Outcome measures included resolution of the lesion, relief of symptoms, systemic and ocular side effects, and recurrence rate.
Results: Five patients including 4 primary OSSNs and one recurrent OSSN received topical interferon alpha?2b. The mean age was 60.2 (range: 52–73) years and mean follow up duration was 10.2 months.
Clinical resolution of the tumor occurred in all cases 2 months after initiation of treatment and no patient developed ocular or systemic complications. No recurrence of OSSN developed during the follow up period.
Conclusion: Topical recombinant IFN?2b appears to be an effective alternative treatment for OSSN with 360o limbal involvement. This approach precludes the high risk of limbal stem cell deficiency which results from surgical excision or topical chemotherapeutic agents.

 
Keyword(s): CONJUNCTIVAL INTRAEPITHELIAL NEOPLASIA, INTERFERON ALPHA 2B, OCULAR SURFACE SQUAMOUS NEOPLASIA, OCULAR SURFACE SQUAMOUS NEOPLASIA
 
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