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Paper Information

Journal:   JOURNAL OF OPHTHALMIC AND VISION RESEARCH   2014 , Volume 9 , Number 4; Page(s) 417 To 422.
 
Paper: 

TOPICAL CYCLOSPORINE A FOR TREATMENT OF DRY EYE DUE TO CHRONIC MUSTARD GAS INJURY

 
DOI: 

10.4103/2008-322X.150803

 
Author(s):  JADIDI KHOSROW, PANAHI YUNES*, EBRAHIMI ALI, MAFI MOSTAFA, NEJAT FARHAD, SAHEBKAR AMIRHOSSEIN
 
* CHEMICAL INJURIES RESEARCH CENTER, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES, MOLLA?SADRA STREET, TEHRAN 19945, IRAN
 
Abstract: 

Purpose: To evaluate the efficacy of topical cyclosporine A (tCsA) for treatment of dry eye disease in patients suffering from chronic ocular complications of mustard gas (MG) injury.
Methods: This interventional case series included patients with MG injury suffering from severe dry eye despite receiving artificial tears and punctal plugs. Patients were administered tCsA 0.05% twice daily for 3 months. Severity of the condition was evaluated by measuring tear osmolarity, ocular surface disease index (OSDI), tear break?up time (TBUT), and Schirmer’s test at baseline and at the end of study.
Results: A total of 34 patients with chronic MG injury and mean age of 47.1±6.5 years were studied.
Compared to baseline values, tear osmolarity (301.7±11.5 vs.286.3±7.9 mOsmol/L, P<0.001) and OSDI (47.5±7.2 vs.42.7±7.1, P<0.001) were significantly improved. Likewise, Schirmer’s test (4.6±1.3 vs. 5±1.3 mm, P<0.001) and TBUT (1.9±1.4 vs.2.7±1.5 s, P<0.001) also significantly recovered at the end of the study.
Conclusion: TCsA 0.05% reduces tear osmolarity and improves dry eye symptoms and can serve as an efficacious treatment for ocular complications in patients with chronic MG injury.

 
Keyword(s): CYCLOSPORINE A, DRY EYE SYNDROME, MUSTARD GAS, TEAR OSMOLARITY
 
 
References: 
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Click to Cite.
APA: Copy

JADIDI, K., & PANAHI, Y., & EBRAHIMI, A., & MAFI, M., & NEJAT, F., & SAHEBKAR, A. (2014). TOPICAL CYCLOSPORINE A FOR TREATMENT OF DRY EYE DUE TO CHRONIC MUSTARD GAS INJURY. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 9(4), 417-422. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507194



Vancouver: Copy

JADIDI KHOSROW, PANAHI YUNES, EBRAHIMI ALI, MAFI MOSTAFA, NEJAT FARHAD, SAHEBKAR AMIRHOSSEIN. TOPICAL CYCLOSPORINE A FOR TREATMENT OF DRY EYE DUE TO CHRONIC MUSTARD GAS INJURY. JOURNAL OF OPHTHALMIC AND VISION RESEARCH. 2014 [cited 2021May08];9(4):417-422. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507194



IEEE: Copy

JADIDI, K., PANAHI, Y., EBRAHIMI, A., MAFI, M., NEJAT, F., SAHEBKAR, A., 2014. TOPICAL CYCLOSPORINE A FOR TREATMENT OF DRY EYE DUE TO CHRONIC MUSTARD GAS INJURY. JOURNAL OF OPHTHALMIC AND VISION RESEARCH, [online] 9(4), pp.417-422. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507194.



 
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