After some years of experience with treatment of choroidal neovascularization (CNV) with intravitreal injections, we now better understand how CNV alters vision and how treatments work. A clear?sighted observation will clarify that CNVs are able to alter the retina and its pigment epithelium, and at the same time induce an external blood retinal barrier breakdown. This breakdown is responsible for retinal edema further aggravating the retinal dysfunction.