Paper Information

Journal:   JENTASHAPIR JOURNAL OF HEALTH RESEARCH (JENTASHAPIR)   FEBRUARY 2016 , Volume 7 , Number 1; Page(s) 1 To 4.
 
Paper: 

IN VITRO CYTOTOXICITY OF PLANTAGO AUSTRALIS ETHANOL EXTRACT USED AS AN ANTI-INFLAMMATORY FOR THE TREATMENT OF ORAL PATHOLOGIES

 
DOI: 

10.17795/jjhr-28515

 
Author(s):  FLORES ISADORA LUANA, GAMBA THIAGO DE OLIVEIRA, DE CARVALHO RODRIGO VARELLA, LUND RAFAEL GUERRA*, ETGES ADRIANA
 
* DENTAL SCHOOL, FEDERAL UNIVERSITY OF PELOTAS, PELOTAS, RIO GRANDE DO SUL, BRAZIL
 
Abstract: 

Background: Plantago australis Lam. is a plant native to southern Brazil largely used to reduce inflammation and improve the healing process. Interestingly, though, there are no previous studies evaluating the cytotoxicity of its ethanolic extract.
Objectives: The main objective is to assess in vitro the cytotoxicity of the crude ethanolic extract of P. australis at different concentrations.
Materials and Methods: The MTT cytotoxicity assay was performed on a 3T3 mouse fibroblast cell line to measure the in vitro cytotoxic activity of the crude formulation.
Results: In vitro analysis showed that the greater the concentration of the extract, the greater the cytotoxicity.
Conclusions: The crude extract of P. australis might be cytotoxic at high concentrations as evaluated against the cell line.

 
Keyword(s): ANTI-INFLAMMATORY, ORAL PATHOLOGY, CYTOTOXICITY, PLANT EXTRACT, PLANTAGO AUSTRALIS
 
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