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Paper Information

Journal:   JOURNAL OF OPHTHALMIC AND VISION RESEARCH   2015 , Volume 10 , Number 1; Page(s) 84 To 86.
 
Paper: 

RESOLUTION OF PRIMARY ACQUIRED MELANOSIS WITH ATYPIA AFTER TREATMENT WITH TOPICAL MITOMYCIN C AND INTERFERON ALFA?2B (CASE REPORT)

 
 
Author(s):  GHASSEMI FARIBA*, GHADIMI HADI, NIKDEL MOJGAN
 
* EYE RESEARCH CENTER, FARABI EYE HOSPITAL, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, SOUTH KARGAR STREET, QAZVIN SQUARE, TEHRAN 13366, IRAN
 
Abstract: 

Purpose: To report a case of primary acquired melanosis (PAM) successfully treated with combined topical mitomycin C and interferon-a2b.
Case Report: A 75-year-old man presented with an extensive unilateral pigmented lesion involving 360° of the bulbar conjunctiva, extending to the fornices and palpebral conjunctiva. Map biopsy confirmed PAM with local atypia. Treatment was initiated with mitomycin C 0.04% eye drops for two courses. Although the lesion markedly responded to the treatment, residual lesions justified further therapy. To avoid ocular surface toxicity induced by excessive mitomycin C exposure, interferon-a2b eye drops were started and continued for 6 months. The pigmented lesion almost completely disappeared and no significant complication or recurrence was observed for 24 months.
Conclusion: Combination therapy using mitomycin C and interferon-a2b for PAM with atypia may be recommended as an effective treatment modality, avoiding the ocular surface toxicity due to excessive mitomycin C exposure.

 
Keyword(s): CONJUNCTIVAL MELANOMA, INTERFERON α2B, MITOMYCIN C, PRIMARY ACQUIRED MELANOSIS
 
 
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APA: Copy

GHASSEMI, F., & GHADIMI, H., & NIKDEL, M. (2015). RESOLUTION OF PRIMARY ACQUIRED MELANOSIS WITH ATYPIA AFTER TREATMENT WITH TOPICAL MITOMYCIN C AND INTERFERON ALFA?2B (CASE REPORT). JOURNAL OF OPHTHALMIC AND VISION RESEARCH, 10(1), 84-86. https://www.sid.ir/en/journal/ViewPaper.aspx?id=507118



Vancouver: Copy

GHASSEMI FARIBA, GHADIMI HADI, NIKDEL MOJGAN. RESOLUTION OF PRIMARY ACQUIRED MELANOSIS WITH ATYPIA AFTER TREATMENT WITH TOPICAL MITOMYCIN C AND INTERFERON ALFA?2B (CASE REPORT). JOURNAL OF OPHTHALMIC AND VISION RESEARCH. 2015 [cited 2021May16];10(1):84-86. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507118



IEEE: Copy

GHASSEMI, F., GHADIMI, H., NIKDEL, M., 2015. RESOLUTION OF PRIMARY ACQUIRED MELANOSIS WITH ATYPIA AFTER TREATMENT WITH TOPICAL MITOMYCIN C AND INTERFERON ALFA?2B (CASE REPORT). JOURNAL OF OPHTHALMIC AND VISION RESEARCH, [online] 10(1), pp.84-86. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=507118.



 
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