Paper Information

Journal:   JOURNAL OF OPHTHALMIC AND VISION RESEARCH   2015 , Volume 10 , Number 1; Page(s) 10 To 15.
 
Paper: 

SENSITIVITY AND SPECIFICITY OF POSTERIOR AND ANTERIOR CORNEAL ELEVATION MEASURED BY ORBSCAN IN DIAGNOSIS OF CLINICAL AND SUBCLINICAL KERATOCONUS

 
DOI: 

10.4103/2008-322X.156085

 
Author(s):  JAFARINASAB MOHAMMAD REZA, SHIRZADEH EBRAHIM*, FEIZI SEPEHR, KARIMIAN FARID, AKABERI ARASH, HASANPOUR HOSEINALI
 
* DEPARTMENT OF OPHTHALMOLOGY, VASEEE HOSPITAL, SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, SABZEVAR, IRAN
 
Abstract: 

Purpose: To determine the sensitivity and specificity of anterior and posterior corneal elevation parameters as determined by Orbscan II (Bausch and Lomb, Rochester, NY, USA) in discriminating between (sub) clinical keratoconus (KCN) and normal corneas.
Methods: This prospective case-control study included 28 eyes with subclinical KCN, 65 with clinical KCN and 141 normal corneas. Anterior and posterior corneal elevation was measured and compared in the central 5-mm corneal zone using Orbscan II.
Results: Receiver operating curves (ROC) curve analyses for posterior corneal elevation showed predictive accuracy in both KCN and subclinical KCN with an area under the curve (AUC) of 0.97 and 0.69, respectively while optimal cutoff points were 51
mm for KCN and 35 mm for subclinical KCN. These values were associated with sensitivity and specificity of 89.23% and 98.58%, respectively, for KCN; and 50.00% and 88.65% for subclinical KCN. ROC curve analyses for anterior corneal elevation showed predictive accuracy in both KCN and subclinical KCN with AUC of 0.97 and 0.69, respectively while optimal cutoff points were 19 mm for KCN and 16 mm for subclinical KCN. These values were associated with sensitivity and specificity of 93.85% and 97.16%, respectively, for KCN; and 60.71% and 87.94% for subclinical KCN.
Conclusion: Anterior and posterior corneal elevation data obtained by Orbscan II can well discriminate between KCN and normal corneas, however the reliability of their indices is lower in differentiating subclinical KCN from normal cases.

 
Keyword(s): CORNEAL ELEVATION, KERATOCONUS, ORBSCAN, RECEIVER OPERATING CURVE, SENSITIVITY, SPECIFICITY
 
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