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Journal:   INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE)   SPRING 2016 , Volume 2 , Number 2; Page(s) 18 To 21.
 
Paper: 

Antifungal Activity Of Caffeine In Combination With Fluconazole Againstcandida Albicans

 
 
Author(s):  Nasrollahi Zahra*, Yadegari Mohammad Hossein
 
* RELIGION AND MEDICINE FACULTY, QOM UNIVERSITY OF MEDICAL SCIENCES, QOM, I.R., IRAN
 
Abstract: 
Background: Iranian (Lahijan) black tea caffeine has been previously shown to have antifungal activity against Candida albicans. The aim of this study was to investigate whether the combination of caffeine and fluconazole (FLU) has an effective antifungal activity on a FLUresistant (MIC>64mgL-1) C. albicans PTCC5027.Materials and Methods: Caffeine from Lahijan black tea was extracted and its pharmacological effects against 20 clinical isolates of FLUsensitive and resistant C. albicans was evaluated by Colony Forming Units (CFU) method. Furthermore, the synergistic effect of caffeine and FLU against PTCC-5027strain was investigated.Results: Our results indicate the antifungal efficacy of Lahijan black tea caffeine on C. albicans isolates and subsequent identification of caffeine in combination with FLU againstPTCC-5027 strain. The concentrations of caffeine causing 90% growth inhibition (MIC90) for PTCC-5027 strain, FLU-resistant and -sensitive C. albicans isolates were 25mgL-1, 24.4mgL-1 and 37.2mgL-1, respectively. The combination of caffeine with FLU showed stronger antifungal activity against C. albicans PTCC5027. The addition of 12.5mgL-1 caffeine to FLU 10-50 mgL-1 (below MIC90) inhibited the growth of C. albicans PTCC5027 by 99.3%–99.7%, the concentrations at which neither caffeine nor FLU alone affected the growth.Conclusion: It can be concluded that caffeine has antifungal effect on C. albicans and in combination with FLU can enhance the antifungal activity of FLU against C. albicans. The synergism of the combination of caffeine and FLU induces multiple antifungal effects, resulting in the use of lower doses of the FLU. It suggests that this can decrease the side effects of antifungal drugs.
 
Keyword(s): CAFFEINE, FLUCONAZOLE, ANTIFUNGAL, CANDIDA ALBICANS
 
 
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APA: Copy

NASROLLAHI, Z., & YADEGARI, M. (2016). ANTIFUNGAL ACTIVITY OF CAFFEINE IN COMBINATION WITH FLUCONAZOLE AGAINSTCANDIDA ALBICANS. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), 2(2), 18-21. https://www.sid.ir/en/journal/ViewPaper.aspx?id=502784



Vancouver: Copy

NASROLLAHI ZAHRA, YADEGARI MOHAMMAD HOSSEIN. ANTIFUNGAL ACTIVITY OF CAFFEINE IN COMBINATION WITH FLUCONAZOLE AGAINSTCANDIDA ALBICANS. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE). 2016 [cited 2022August11];2(2):18-21. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=502784



IEEE: Copy

NASROLLAHI, Z., YADEGARI, M., 2016. ANTIFUNGAL ACTIVITY OF CAFFEINE IN COMBINATION WITH FLUCONAZOLE AGAINSTCANDIDA ALBICANS. INFECTION EPIDEMIOLOGY AND MICROBIOLOGY (INFECTION EPIDEMIOLOGY AND MEDICINE), [online] 2(2), pp.18-21. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=502784.



 
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