Paper Information

Journal:   PAYESH   OCTOBER 2003 , Volume 2 , Number 4; Page(s) 291 To 295.
 
Paper: 

SEROPREVALENCE OF HEPATITIS C AND RISK FACTORS IN HEMODIALYSIS PATIENTS IN GUILAN PROVINCE, IRAN

 
 
Author(s):  MOHTASHAM AMIRI Z.*, JAEFARI SHAKIB A., TOORCHI ROODSARI M.
 
* Department of Social Medicine, Guilan Faculty of Medical Sciences, Rasht, Iran
 
Abstract: 

Objective(s): To determine HCV infection in hemodialysis patients in Guilan, Iran.
Material & Methods: In this cross-sectional study, all 298 hemodialysis patients with regard to their sex, age length of time on dialysis and previous kidney transplantation were evaluated in Guilan Province. Blood samples screened for anti HCV antibodies by a second generation Enzyme-Linked Immunosorbent Assay (ELISA II). Positive samples were retested for confirmatory immunoblotting assay. Analysis was carried out using the Epi6 software.
Results: An overall prevalence of 24.8% (95%CI: 19.9-29.7) was found, ranging from 9% to 40% depending on the dialysis unit. Of the 298 cases, 80 were found to be seropositive by ELISA and 74 were confirmed positive by Western blot assay.
The relationship between sex, age and seropositive results was not significant but relationship between length of time on dialysis and history of kidney rejection with seropositive results was significant. Eleven patients had rejected kidney. Of these 7 cases were seropositive.
Conclusion: These data suggest that nasocomial transmission may play a role in the spreed of HCV in the dialysis units. A separate hemodialysis system should be used for seropositive HCV patients.

 
Keyword(s): EPIDEMIOLOGY, HEPATITIS C, HEMODIALYSIS
 
References: 
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  Persian Abstract Yearly Visit 143
 
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