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Paper Information

Journal:   IRANIAN HEART JOURNAL (IHJ)   Winter 2003 , Volume 4 , Number 4; Page(s) 63 To 67.
 
Paper: 

COMPARISON OF SERUM DIGOXIN LEVEL AND CLINICAL RESPONSE IN PATIENTS WITH CHRONIC ATRIAL FIBRILLATION IN TWO DIFFERENT WAYS OF CONTINUOUS AND INTERRUPTED USE

 
 
Author(s):  NEMATIPOUR E., SABOUR F., NAMAZI S.
 
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Abstract: 
Background- Digoxin prescription with an interruption of one or two days a week is ‎frequently used in Iran. We compared this kind of digoxin prescription with an ‎uninterrupted one through the determination of serum digoxin level and clinical ‎response in Iranian patients
‎‏.‏ Methods- This study was designed as a crossover clinical trial on 28 patients suffering ‎from chronic atrial fibrillation (AF), and the two different methods of digoxin ‎prescription were compared through achieving therapeutic range of serum digoxin ‎level and clinical response as control of heart rate in patients with chronic AF‏.‏ Results- The serum digoxin concentration in interrupted consumption, the day before ‎‎(0.885 ± 0.29 ng/ml) and after (0.614 ± 0.35 ng/ml) interruption was significantly ‎lower than the continuous form (1.157 ± 0.3 ng/ml), p < 0.05. About 35% of the ‎patients in the interrupted schedule of digoxin had plasma levels lower than 0.8 ng/ml ‎‎(minimum therapeutic range), compared with no one in the continuous schedule. Also ‎none of the patients in the continuous consumption group showed clinical and/or ‎electrocardiographic signs of digoxin toxicity. The mean heart rate in interrupted use ‎on the day before (84.82 ± 7.2 beats/min) and after (86.5 ± 3.8 beats/min) interruption ‎was significantly higher than that in the continuous form (75.9 ± 5.2 beats/ min), p < ‎‎0.05‎‏.‏ ‎
‎ Conclusion- This study showed that the continuous use of digoxin has the advantage ‎of achieving the therapeutic range and better controlling the heart rate in patients with ‎AF rhythm and could be the preferred form of prescription in the majority of our ‎patients, as it is in nearly all the countries around the world (Iranian Heart Journal 2003; 4 ‎‎(4):6367).‎
 
Keyword(s): DIGOXIN .ARRHYTHMIA .TRIAL FIBRILLATION .PRESCRIPTION
 
 
References: 
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APA: Copy

NEMATIPOUR, E., & SABOUR, F., & NAMAZI, S. (2003). COMPARISON OF SERUM DIGOXIN LEVEL AND CLINICAL RESPONSE IN PATIENTS WITH CHRONIC ATRIAL FIBRILLATION IN TWO DIFFERENT WAYS OF CONTINUOUS AND INTERRUPTED USE. IRANIAN HEART JOURNAL (IHJ), 4(4), 63-67. https://www.sid.ir/en/journal/ViewPaper.aspx?id=4788



Vancouver: Copy

NEMATIPOUR E., SABOUR F., NAMAZI S.. COMPARISON OF SERUM DIGOXIN LEVEL AND CLINICAL RESPONSE IN PATIENTS WITH CHRONIC ATRIAL FIBRILLATION IN TWO DIFFERENT WAYS OF CONTINUOUS AND INTERRUPTED USE. IRANIAN HEART JOURNAL (IHJ). 2003 [cited 2021June23];4(4):63-67. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=4788



IEEE: Copy

NEMATIPOUR, E., SABOUR, F., NAMAZI, S., 2003. COMPARISON OF SERUM DIGOXIN LEVEL AND CLINICAL RESPONSE IN PATIENTS WITH CHRONIC ATRIAL FIBRILLATION IN TWO DIFFERENT WAYS OF CONTINUOUS AND INTERRUPTED USE. IRANIAN HEART JOURNAL (IHJ), [online] 4(4), pp.63-67. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=4788.



 
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