Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   January 2003 , Volume 6 , Number 1; Page(s) 35 To 39.
 
Paper: 

EFFECTS OF TEUCRIUM POLIUM ON ORAL GLUCOSE TOLERANCE TEST, REGENERATION OF PANCREATIC ISLETS AND ACTIVITY OF HEPATIC GLUCOKINASE IN DIABETIC RATS

 
 
Author(s):  VESAL M.*, ZAL F., VASEEI M.
 
* 
 
Abstract: 
Background and Objective - Hepatotoxicity associated with the hypoglycemic effects ‎of an aqueous extract of Teucrium polium was previously described. In this ‎investigation, the effects of the extract on oral glucose tolerance test, regeneration of ‎pancreatic islets and hepatic glucokinase activity of streptozocin-induced diabetic rats ‎were studied‏.‏‎
‎ Methods - An aqueous extract of T. polium was fed by gavage tube to healthy and ‎streptozocin-induced diabetic rats for several days. Oral glucose tolerance, number of ‎pancreatic islets and hepatic glucokinase activity were measured using standard ‎methods and compared between diabetic and healthy rats‏.‏‎
‎ Results - In diabetic animals, the aqueous extract caused a significant reduction (p < ‎‎0.001) in the level of serum glucose during oral glucose tolerance tests. The number ‎of pancreatic islets per unit area significantly increased (p < 0.01) and glucokinase ‎activity was significantly elevated (p < 0.01) in diabetic animals treated with the ‎extract‏.‏‎
‎ Conclusion - Although aqueous extract of T. polium contains some hepatotoxic ‎compounds, it also contains components that are beneficial in the treatment of ‎streptozocin-induced diabetes‏.‏
 
Keyword(s): DIABETES MELLITUS, GLUCOSE TOLERANCE TEST, ISLET OF LANGERHANS E RATS TEUCRIUM POLIUM
 
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