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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   January 2003 , Volume 6 , Number 1; Page(s) 35 To 39.
 
Paper: 

EFFECTS OF TEUCRIUM POLIUM ON ORAL GLUCOSE TOLERANCE TEST, REGENERATION OF PANCREATIC ISLETS AND ACTIVITY OF HEPATIC GLUCOKINASE IN DIABETIC RATS

 
 
Author(s):  VESAL M.*, ZAL F., VASEEI M.
 
* 
 
Abstract: 
Background and Objective - Hepatotoxicity associated with the hypoglycemic effects ‎of an aqueous extract of Teucrium polium was previously described. In this ‎investigation, the effects of the extract on oral glucose tolerance test, regeneration of ‎pancreatic islets and hepatic glucokinase activity of streptozocin-induced diabetic rats ‎were studied‏.‏‎
‎ Methods - An aqueous extract of T. polium was fed by gavage tube to healthy and ‎streptozocin-induced diabetic rats for several days. Oral glucose tolerance, number of ‎pancreatic islets and hepatic glucokinase activity were measured using standard ‎methods and compared between diabetic and healthy rats‏.‏‎
‎ Results - In diabetic animals, the aqueous extract caused a significant reduction (p < ‎‎0.001) in the level of serum glucose during oral glucose tolerance tests. The number ‎of pancreatic islets per unit area significantly increased (p < 0.01) and glucokinase ‎activity was significantly elevated (p < 0.01) in diabetic animals treated with the ‎extract‏.‏‎
‎ Conclusion - Although aqueous extract of T. polium contains some hepatotoxic ‎compounds, it also contains components that are beneficial in the treatment of ‎streptozocin-induced diabetes‏.‏
 
Keyword(s): DIABETES MELLITUS, GLUCOSE TOLERANCE TEST, ISLET OF LANGERHANS E RATS TEUCRIUM POLIUM
 
 
References: 
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Cite:
APA: Copy

VESAL, M., & ZAL, F., & VASEEI, M. (2003). EFFECTS OF TEUCRIUM POLIUM ON ORAL GLUCOSE TOLERANCE TEST, REGENERATION OF PANCREATIC ISLETS AND ACTIVITY OF HEPATIC GLUCOKINASE IN DIABETIC RATS. ARCHIVES OF IRANIAN MEDICINE, 6(1), 35-39. https://www.sid.ir/en/journal/ViewPaper.aspx?id=4770



Vancouver: Copy

VESAL M., ZAL F., VASEEI M.. EFFECTS OF TEUCRIUM POLIUM ON ORAL GLUCOSE TOLERANCE TEST, REGENERATION OF PANCREATIC ISLETS AND ACTIVITY OF HEPATIC GLUCOKINASE IN DIABETIC RATS. ARCHIVES OF IRANIAN MEDICINE. 2003 [cited 2021April17];6(1):35-39. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=4770



IEEE: Copy

VESAL, M., ZAL, F., VASEEI, M., 2003. EFFECTS OF TEUCRIUM POLIUM ON ORAL GLUCOSE TOLERANCE TEST, REGENERATION OF PANCREATIC ISLETS AND ACTIVITY OF HEPATIC GLUCOKINASE IN DIABETIC RATS. ARCHIVES OF IRANIAN MEDICINE, [online] 6(1), pp.35-39. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=4770>.



 
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