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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   April 2003 , Volume 6 , Number 2; Page(s) 86 To 90.
 
Paper: 

SUCCESSFUL TREATMENT OF VITILIGO WITH PUNCH GRAFT FOLLOWED BY OUTDOOR TOPICAL PSORALEN PLUS ULTRAVIOLET A RADIATION

 
 
Author(s):  HALAJI Z.*, DANESH PAZHOUH MARYAM, REZAEI KHIABANLOU S.
 
* Tehran, Iran
 
Abstract: 
Background and Objective - Punch grafting is a therapy for vitiligo but, to our knowledge, its combination with outdoor topical psoralen plus ultraviolet A radiation (PUVA) has not yet been studied. This study was designed to evaluate the efficacy of combination of punch graft and outdoor topical PUVA in recalcitrant vitiligo. Methods - The study was performed in Razi Hospital, Tehran in 2000. After obtaining informed consent, 20 patients with stable and refractory vitiligo (4 segmental, 8 focal and 8 generalized) underwent treatment with punch grafting. After 3 months, outdoor topical PUVA with 8-methoxypsoralen was instituted and continued for a maximum of 4 months. Results - After the 3 months of punch grafting, only nine patients experienced 33 - 66% repigmentation. Four months after starting topical outdoor PUVA, 13 patients experienced 90 - 100% and three patients 25 - 50% repigmentation. One focal and three generalized patients showed no response. Conclusion - The combination of punch grafting and topical PUVA may be an effective treatment in stable and intractable vitiligo, especially the segmental and localized types.
 
Keyword(s): PUNCH GRAFTING, TOPICAL PUVA, VITILIGO
 
References: 
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