Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   April 2004 , Volume 7 , Number 2; Page(s) 93 To 97.
 
Paper: 

THE INSTANT DEATH SYMPHONY IS LIKELY TO BE ORCHESTRATED BY CREATINE KINASE OF THE MID-ASIAN VIPERIDAE VENOM

 
 
Author(s):  MARKARIAN A., ARKHANGELSKY S., KOUZNETSOV D.*, ORLOVA M.
 
* Russian Academy of Science,
 
Abstract: 
Background - The aim of present study was to investigate a possible link between the creatine kinase (CK) content in the V. xanthia raddei venom and its acute toxicity values.
Methods - Creatine kinase, the ATP-generating enzyme belonging to a phosphotransferases family, has been completely purified from the venom of Vipera xanthia raddei using a novel method of affinity chromatography on ADP-Sepharose.
Results - This enzyme is proven to be a compound for determining an acute toxicity degree provided by the intramuscular (IM) venom injection to mice. Not being a toxic agent itself, this 40 kDa monomer protein, however, increases the toxicity level when added to a natural total or creatine kinase-depleted venom composition.
Conclusion - A possible significance of the data presented for research on a snake bite promoted coagulopathies is under discussion.
 
Keyword(s): CREATINE KINASE, DISSEMINATED INTRAVASCULAR COAGULATION (DIC) SYNDROME, VIPERIDAE VENOM, TOXIC COAGULOPATHY
 
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