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Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2003 , Volume 61 , Number 1; Page(s) 80 To 89.
 
Paper: 

HLA-DRB, DQA1 AND DQB1 ALLELES AND HAPLOTYPES FRECUENCY IN IRANIAN PULMONAR TUBERCULOSIS PATIENTS AND NORMAL CONTROL

 
 
Author(s):  JABARI H.*, AMIR ZARGAR A., HAJI ABD ALBAGHI MAHBOUBEH, NIKBIN B., KHOSRAVI F., NIKNAM MANDANA, ANSARI B., MORADI B., YALDA A.
 
* 
 
Abstract: 

Introduction: Tuberculosis is the most widespread epidemy of the world. It is estimated that one third of the worlds population are infected with mycoboacterium tuberculosis, producing a burden of 8-10 millions of new cases and 3 millions of dead" each year in the world. Epidemiological studies are indicating that genetic susceptibility can predispose to prevent from tuberculosis infection and its severity.
Methods and Materials: In the present case-control analytic study, 40 sputum positive pulmonary T. B. patients HLA-class II alleles (DRB, DQA 1 and DQB 1) are detected and compared with 100 healthy subjects by PCR-ssp method for the first time in Iran.
Results: The frequencies of alleles DQA1 *0101 [OR: 2.662 (95% CI: 1.15-6.44) and DRB*07 (Pc= 0.0252, OR: 2.710 (95% CI: 1.197-6.135) were significantly) increased in P.T.B patients when compared with healthy subjects. By contrast, frequencies of alleles DQA1*0301 [OR: 0.254 (95% CI: 0.075-0.865): and DQA1* 0501 [OR: 0.539 (95% CI: 0.304-0.954)] were significantly decreased it patients with P.T.B. There was no significant statistical predisposition/ prevention it DQB 1 locus alleles frequency or any haplotype disequilibrium.
Conclusion: The HLA system appears to have an important genetic influence on P.T.B. development.

 
Keyword(s): HLA (HUMAN LEUKOCYTE ANTIGEN), P.T.B. (PULMONARY TUBERCULOSIS), PCR (PULMONARY CHAIN REACTION)
 
References: 
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