Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   2003 , Volume 61 , Number 1; Page(s) 57 To 63.
 
Paper: 

MORPHOLOGICAL STUDIES OF PLACENTA OF MOUSE (BALB/C) ADDICTED TO HEROIN

 
 
Author(s):  TOUTIAN Z.*, FAZELIPOUR S., KIANI S.B.
 
* 
 
Abstract: 

Introduction: In this research, the effects of heroin in the placenta of addicted mouse were studied properly.
Methods and Materials: For this reason we used of addicted female mice before, during and after gestation and also a control group of healthy mice. The male mice were in two groups of addicted and healthy. Heroin were used in concentration of 0.1, 0.3 and 0.5 mg/ml in tap water. Placenta of mice separated from uterus in 17th days of gestation and compared with placenta of non addicted mice, with diameter, weight and abnormal conformations.
Results: The results showed that there were significant comparison between diameters and weights of these two groups (p<0.0001). In morphological studies, there were changes in size (small placenta, giant placenta), joining and hemorhagic state placentas.
Conclusion: According to the results we concluded that the opioids even with with very small doses can induce harmful effects on gestation and non-pure heroin in Iranian smugglery is much more harmful than the pure one.

 
Keyword(s): PLACENTA, MOUS, HEROIN
 
References: 
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