BERBERINE IMPROVES LIVER FAILURE INDUCED BY FERROUS SULFATE IN RAT

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KEYKHA SAMANEH; GHOLAMPOUR FIROZEH; VATANPARAST JAFAR; MONSEFI MALIHATOZAMAN

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Paper Information

Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2014 | Volume:3 | Issue:SUPPL. (1) Page(s): 184-184

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Title

BERBERINE IMPROVES LIVER FAILURE INDUCED BY FERROUS SULFATE IN RAT

Author(s)

KEYKHA SAMANEH | GHOLAMPOUR FIROZEH | VATANPARAST JAFAR | MONSEFI MALIHATOZAMAN

Keywords

ALANINE AMINOTRANSFERASE

ASPARTATE AMINOTRANSFERASE

BERBERINE

LIPID PEROXIDATION

LIVER

FERROUS SULFATE

Abstract

As LIVER is the major site of iron storage, it is susceptible to damage from iron toxicity. It has been demonstrated that FERROUS SULFATE induces hepatic toxicity in rats. BERBERINE, an isoquinoline alkaloid, has a wide range of pharmacological effects, including anti-inflammation. Thus, the effects BERBERINE on LIVER injury induced by FERROUS SULFATE was investigated in rat. LIVER failure was induced by i.p. injection of FERROUS SULFATE (30 mg/Kg/day) for 14 day. In final blood samples collected for determination of the plasma creatinine, blood urea nitrogen (BUN), ASPARTATE AMINOTRANSFERASE (AST), ALANINE AMINOTRANSFERASE (ALT) and alkaline phosphatase (ALP) concentration. Then LIVER samples were removed and preserved for histological studies and estimation of LIPID PEROXIDATION. BERBERINE (10 mg/kg/day) was administered 14 days by gavage. FERROUS SULFATE caused a significant reduction in renal function, increase of LIPID PEROXIDATION, increase in LIVER inflammation, demonstrated by elevation in plasma levels of AST, ALT and ALP as well induction of hepatic histological damages. BERBERINE treatment reversed the parameters of LIVER injury, increase of LIPID PEROXIDATION and LIVER enzymes levels as well as reduced total hepatic histopathological scores. These data suggest the protective effect of BERBERINE against LIVER dysfunction induced by FERROUS SULFATE in rats.

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APA: Copy

KEYKHA, SAMANEH, GHOLAMPOUR, FIROZEH, VATANPARAST, JAFAR, & MONSEFI, MALIHATOZAMAN. (2014). BERBERINE IMPROVES LIVER FAILURE INDUCED BY FERROUS SULFATE IN RAT. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 184-184. SID. https://sid.ir/paper/335991/en

Vancouver: Copy

KEYKHA SAMANEH, GHOLAMPOUR FIROZEH, VATANPARAST JAFAR, MONSEFI MALIHATOZAMAN. BERBERINE IMPROVES LIVER FAILURE INDUCED BY FERROUS SULFATE IN RAT. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):184-184. Available from: https://sid.ir/paper/335991/en

IEEE: Copy

SAMANEH KEYKHA, FIROZEH GHOLAMPOUR, JAFAR VATANPARAST, and MALIHATOZAMAN MONSEFI, “BERBERINE IMPROVES LIVER FAILURE INDUCED BY FERROUS SULFATE IN RAT,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 184–184, 2014, [Online]. Available: https://sid.ir/paper/335991/en

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