Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   FALL 2003 , Volume 10 , Number SUPPLEMENT 3; Page(s) 9 To 15.
 
Paper: 

EVALUATION OF OVARIECTOMY EFFECT ON WOUND HEALING PROCESS IN SOFT AND HARD TISSUE IN RAT

 
 
Author(s):  HOUSHMAND BEHZAD*, MOVAHEDIAN B., ESLAMI B., MOSHREF M., KASAEI H., KOLAHGHOCHI N.
 
* DEPARTMENT OF PERIODONTOLOGY, SCHOOL OF DENTISTRY HAMADAN UNIVERSITY OF MEDICAL SCIENCES & HEALTH SERVICES, HAMADAN, IRAN
 
Abstract: 

In this study wound healing process in soft and hard tissues of the gingival area and the Mandibular bone of rats whose ovary glands were removed bilaterally (as samples which are similar to menopause period in human) was assessed histologically and hisomorphoemtrically and results write compared with those of control group. For performing this study, 20 rats were chosen and divided into two groups with ten rats in each group. In one group of rats bilateral ovariectomy was applied and in another group, simi operation was done except for ovariectomy (Sham operation). 5 months after ovariectomy, a defect was created (Sham operation), 5 months after ovariectomy, a defect was created in gingival area and mandibular bone of lower right central incisor in 5 mm lower than gingival margin which was 5 mm deep with a ‎‎1.3mm diameter. In 1, 4, 7, 21 and 42 days after creation of the defect, biopsies were taken from the defect area and histologic and histomorphometic studies were done. Histological assessment sections consisted of clotting formation, degree and kind of inflammation and granulation tissue and degree and nature of bone formation.
Results demonstrated that during the first days, the inflammation was more severe in the control group rather than the study group, but gradually the inflammation process became similar in both groups. The produced fibrous tissue in control group was also more than the study group on the 7th day samples, producing of new bone was obvious in the bone defect margins in both groups. On the 21st day, formation of woven bone was observed in both groups. On the 42nd day, the produced bone in both groups was lamellar, but histomorphometic studies showed that bone formation in the control group was greater than the study group.
Few studies through histologic evaluation of wound healing process in soft and hard (bone) tissues after ovariectomy operation have been done. In this study wound healing process in soft tissue in ovariectomized rats has been decelerated and the amount of new bone formation is decreased‏.‏

 
Keyword(s): MENOPAUSE, OSTEOPOROSIS, OVARIECTOMY, WOUND HEALIG
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 78
 
Latest on Blog
Enter SID Blog