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Paper Information

Journal:   JOURNAL OF VETERINARY RESEARCH   2003 , Volume 58 , Number 2; Page(s) 111 To 114.
 
Paper: 

THE EFFECT OF DEXAMETHASONE TO PREVENT INDUCED LUTEOLYSIS IN HOLSTEIN HEIFER

 
 
Author(s):  MOHAMMAD SADEGH M.*, HOVARESHTI P., BOLURCHI M., BOKAEI S., NOUROUZIAN I.*
 
* Department of Clinical Sciences Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
 
Abstract: 
Objective: Study the effect of dexamethasone to inhibit induced corpus luteal regression with PGF2α treatment.
Design: Clinical trail (Replacement treatment design)
Animals: Seventeen Holstein heifers at 15- 17 month of age and 340kg mean body weight.
Treatment: 1-Dexamethasone (I5 mg, Im, Colvasone, Nor broke Co. England). 2- PGF2
α (25 mg, Im, Lutalyse, Upjohn Co. USA)
Procedure: The numbers, of animals showing lutolysis after the injection of PGF2
α on day 9 of synchronized estrous cycle (control group) were estimated and then, on the following estrous cycle, the numbers of animals showing lutolysis after the injection of dexamethasone on day 8, and PGF2α on day 9 (test group) were estimated. Blood samples were collected on day 8 and 13 of the cycle to assay serum progesterone levels and demonstrate the activity of CL. Estrous detection and rectal polpation of corpus luteum were established through day 8 to 13 of the cycle.
Statistical analysis: Fisher exact (two tailed) test.
Results: Corpora lutea of 17 animals of control group (100%) were regressed after the injection of the PGF2
α but CLs of 6 animals of test group (35.3%) were not regressed. The injection of dexamethasone, 24h before the induction of luteolysis with PGF2α on day 9 of the estrous cycle significantly inhibited lutolysis (P >0.05).
Clinical Implications: it seems that luteolysis effect of PGF2
α which is needed in the case of estrous synchronization and/or uterine injection, may be impaired in treated animal with dexamethasone as an anti -anti-inflammatory amatory drug
 
Keyword(s): DEXAMETHASONE, DINAPROST, PGF2Α, INDUCTION OF LUTEOLYSIS, INHIBITION OF LUTEOLYSIS
 
References: 
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