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Paper Information

Journal:   IRANIAN JOURNAL OF OTORHINOLARYNGOLOGY   Spring 2003 , Volume 15 , Number 1 (31); Page(s) 11 To 19.
 
Paper: 

THE PRESENCE OF ESTROGEN AND PROGESTERONE RECEPTORS IN INTRACRANIAL VISTIBULAR SCHWANOMA EVALUATED WITH IMMUNOHISTOCHEMICAL ASSAY

 
 
Author(s):  BIRJANDI A.R., ETEMAD REZAEI H., ABD ALHOSSEINPOUR H., BAHAR VAHDAT H., GHIASI T., GHAFARZADEGAN KAMRAN
 
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Abstract: 
Objective: The presence of estrogen and progesterone receptors evaluated in intra cranial vestibular schwanoma. Material and Method: In this study 31 patients with acoustic neuroma operated between 1994 and 2001 in Ghaem Hospital were studied retrospectively. The paraffined biopsies were evaluated for presence of the estrogen and progesterone receptors by immunohistochemical assay. Medical records were reviewed for demographic characteristics of the patients, their clinical manifestations, location of tumors, surgical removal, and the size of tumors. Results: There were 18 (58.1%) women and 13 (41.9%) men with average age of 40.9 years. The most common clinical manifestation was hearing impairment (25 cases). In eleven patients (35.5%) acoustic neuroma was in the right cerebellopontine angle (CPA), in 19 (61.3%) in left, and one patient with neurofibromatosis\ type II had bilateral vestibular schwanoma. Eighteen patients (58.1%) had progesterone receptors were detected. There was no relation between the patients characteristics (sex, age, and location of tumor) and the progesterone receptors (P=0.739, P=0.253, P=0.466, respectively). Conclusion: Since the receptors of progesterone and estrogen were found in significant numbers in our patients, we suggest further studies on the role of these receptors in this tumor and their probable importance in treatment of acoustic neuroma.
 
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