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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   MAY 2014 , Volume 9 , Number 2; Page(s) 0 To 0.
 
Paper: 

EFFECT OF AQUEOUS ALLIUM CEPA AND IXORA BRACHIATA ROOT EXTRACT ON LEISHMANIA MAJOR PROMASTIGOTES

 
 
Author(s):  SADEGHI NEJAD BATOOL*, SAKI JASEM, AZISH MARYAM
 
* DEPARTMENT OF MEDICAL MYCOLOGY, CELLULAR AND MOLECULAR RESEARCH CENTER, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IR IRAN.
 
Abstract: 

Background: Leishmaniasis is a major worldwide public health problem with about two to three million humans threatened by this disease annually. Allium cepa (onion) is an important dietary vegetable and was used as a herbal medicine for centuries. The root of Ixora brachiata is medicinally important.
Objectives: The aim of this study was to investigate the anti-Leishmania effect of the ethanolic and methanolic extracts of Ixora brachiata root and aqueous onion extracts on Leishmania major promastigotes.
Patients and Methods: The parasites isolated from cutaneous leishmaniasis were exposed with different concentrations of selected plant extracts and their inhibitory effects on the promastigotes were evaluated after 24 and 48 hours.
Results: Among tested plant extracts, Ixora brachiata root extracts revealed the best activity against Leishmania major promastigotes with IC100 value of 2.5 mg/mL and IC50 value of 0.078 mg/mL.
Conclusions: This study showed that aqueous Allium cepa and Ixora brachiata root extracts as natural products could be used as alternative drugs in treatment of leishmaniasis.

 
Keyword(s): LEISHMANIA MAJOR, ALLIUM CEPA, IXORA BRACHIATE, LEISHMANIASIS
 
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