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Paper Information

Journal:   JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS   MAY 2014 , Volume 9 , Number 2; Page(s) 0 To 0.
 
Paper: 

DETECTION OF ANTISEPTIC-RESISTANCE GENES IN PSEUDOMONAS AND ACINETOBACTER SPP. ISOLATED FROM BURN PATIENTS

 
 
Author(s):  MAHZOUNIEH MOHAMMAD REZA*, KHOSHNOOD SHEIDA, EBRAHIMI AZIZOLLAH, HABIBIAN SAEID, YAGHOUBIAN MARYAM
 
* DEPARTMENT OF PATHOBIOLOGY, FACULTY OF VETERINARY MEDICINE, SHAHREKORD UNIVERSITY, SHAHREKORD, IR IRAN
 
Abstract: 

Background: Quaternary ammonium compounds (QAC), which contain benzalkonium chloride as the most widely used agent, are employed as wound and skin antiseptics, as well as disinfectants in hospitals. The resistance mechanism to disinfectants is usually determine by genes which are related to resistance to quaternary ammonium compounds, namely, qacE, qacDE1, qacDE1 that are found in Gram-negative bacteria.
Objectives: The aim of this study was to determine the incidence of antiseptic resistance genes, qacE and qac
DE1, in clinical isolates of Pseudomonas aeruginosa and Acinetobacter bumanii.
Materials and Methods: In this study, 83 clinical isolates of Pseudomonas aeruginosa, and 5 isolates of Acinetobacter baumannii from burn hospitals in Tehran and Isfahan provinces in 2010-2011, were tested by the PCR method.
Results: Out of the 83 clinical isolates of Pseudomonas aeruginosa, 49 isolates (50%) had the qacE gene, and 76 isolates (91.5%) had the qac
DE1 gene. In addition, in 5 isolates of Acinetobacter bumanii, 2 isolates (40%) had the qacE gene, and 4 isolates (80%) had the qacDE1 gene.
Conclusions: This study shows that the genes which harbored resistance to quaternary ammonium compound antiseptics are widespread among Pseudomonas aeruginosa and Acinetobacter bumanii isolates in burn patients.

 
Keyword(s): PSEUDOMONAS AERUGINOSA, ACINETOBACTER, QUATERNARY AMMONIUM COMPOUNDS
 
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