Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   NOVEMBER 2014 , Volume 17 , Number 11; Page(s) 763 To 770.
 
Paper: 

PREVALENCE AND CHARACTERISTICS OF EPSTEIN–BARR VIRUS-ASSOCIATED GASTRIC CANCER IN IRAN

 
 
Author(s):  FAGHIHLOO EBRAHIM, SAREMI MOHAMMAD REZA, MAHABADI MOSTAFA, AKBARI HASSAN, SABERFAR ESMAIL*
 
* RESEARCH CENTER OF VIRUS AND VACCINE, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

BACKGROUND/AIMS: Gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide and is the most frequent cancer in Iran. Epstein-Barr virus (EBV) has been shown to be associated with gastric cancer. The present study was carried out to investigate the prevalence of Epstein-Barr virus (EBV) associated gastric cancer among Iranian patients.
METHODS: Ninety formalin fixed paraffin-embedded cases of gastric cancer were studied. The specimens were investigated for the presence of the EBV genome by quantitative real-time polymerase chain reaction.
RESULTS: Of ninety specimens, EBV was detected in six cases (6.66%). The mean age for patients EBV-positive gastric carcinomas was 72.1 years, whereas the mean age for the entire group was 65.7 years. Four out of 64 (6.25%) male patients and 2 out of 26 (7.69%) female cases were positive for EBV. According to anatomic location, EBV was detected in 4 out of 39 (10.25% ) gastric cancer were located in cardia and 2 out of 26 (7.69%) gastric cancer were located in middle/corpus.
CONCLUSIONS: The present study shows that the frequency of EBV-associated gastric carcinoma in Iran is low. Differences of EBV-associated gastric carcinoma incidence in different countries may reflect the epidemiologic factors and dietary habits. Further analysis of clinical pathology features of EBV-associated gastric carcinoma using a larger number of cases would give invaluable insights into its etiology.

 
Keyword(s): EPSTEIN, BARR, GASTRIC CANCER, IRAN
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 98
 
Latest on Blog
Enter SID Blog